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L(ou)sy miRNA targets?

Authors

  • N. Rajewsky

Journal

  • Nature Structural & Molecular Biology

Citation

  • Nat Struct Mol Biol 13 (9): 754-755

Abstract

  • MicroRNAs (miRNAs) are noncoding small RNAs thought to post-transcriptionally regulate many metazoan genes by binding to partially complementary sites in target messenger RNAs. In this issue, Didiano and Hobert examine known and predicted targets of the nematode lsy-6 miRNA, question the general validity of previously proposed rules about miRNA-target interactions and suggest that many functional miRNA targets might be context dependent, as seen in metazoan gene regulation by transcription factors.


DOI

doi:10.1038/nsmb0906-754