- C. Birchmeier
- W. Birchmeier
- E. Gherardi
- G.F. Vande Woude
- Nature Reviews Molecular Cell Biology
- Nat Rev Mol Cell Biol 4 (12): 915-925
Hepatocyte growth factor/scatter factor and its receptor, the tyrosine kinase Met, arose late in evolution and are unique to vertebrates. In spite of this, Met uses molecules such as Gab1 — homologues of which are present in Caenorhabditis elegans and Drosophila melanogaster — for downstream signalling. Pivotal roles for Met in development and cancer have been established: Met controls cell migration and growth in embryogenesis; it also controls growth, invasion and metastasis in cancer cells; and activating Met mutations predispose to human cancer.