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Met, metastasis, motility and more

Authors

  • C. Birchmeier
  • W. Birchmeier
  • E. Gherardi
  • G.F. Vande Woude

Journal

  • Nature Reviews Molecular Cell Biology

Citation

  • Nat Rev Mol Cell Biol 4 (12): 915-925

Abstract

  • Hepatocyte growth factor/scatter factor and its receptor, the tyrosine kinase Met, arose late in evolution and are unique to vertebrates. In spite of this, Met uses molecules such as Gab1 — homologues of which are present in Caenorhabditis elegans and Drosophila melanogaster — for downstream signalling. Pivotal roles for Met in development and cancer have been established: Met controls cell migration and growth in embryogenesis; it also controls growth, invasion and metastasis in cancer cells; and activating Met mutations predispose to human cancer.


DOI

doi:10.1038/nrm1261