Modeling morphodynamic phenotypes and dynamic regimes of cell motion


  • M. Enculescu
  • M. Falcke


  • Advances in Experimental Medicine and Biology


  • Adv Exp Med Biol 736 (3): 337-358


  • Many cellular processes and signaling pathways converge onto cell morphology and cell motion, which share important components. The mechanisms used for propulsion could also be responsible for shape changes, if they are capable of generating the rich observed variety of dynamic regimes. Additionally, the analysis of cell shape changes in space and time promises insight into the state of the cytoskeleton and signaling pathways controlling it. While this has been obvious for some time by now, little effort has been made to systematically and quantitatively explore this source of information. First pioneering experimental work revealed morphodynamic phenotypes which can be associated with dynamic regimes like oscillations and excitability. Here, we review the current state of modeling of morphodynamic phenotypes, the experimental results and discuss the ideas on the mechanisms driving shape changes which are suggested by modeling.