The mTPH2 C1473G single nucleotide polymorphism is not responsible for behavioural differences between mouse strains


  • K. Tenner
  • F. Qadri
  • B. Bert
  • J.P. Voigt
  • M. Bader


  • Neuroscience Letters


  • Neurosci Lett 431 (1): 21-25


  • Tryptophan hydroxylase 2 (TPH2) is the rate limiting enzyme of serotonin synthesis in the brain. A recently described functional (C1473G) single nucleotide polymorphism in mouse TPH2 resulting in vitro in a strongly decreased enzymatic activity was suspected to be responsible for the observed differences in 5-HT levels and behaviour between mice strains. We bred two substrains of C57BL/6 mice carrying the two isoforms and could show that both exhibit equal TPH activity, brain 5-HT content and behaviour. These data indicate that the distinct behavioural characteristics of mouse strains are not due to differences in TPH2 activity, but to other variations in the genetic background.