Myb partnerships


  • X. Mo
  • E. Kowenz-Leutz
  • A. Leutz


  • 239-256


  • The c-Myb protein is a DNA binding transcription factor that coordinates proliferation and differentiation of haemopoietic cells. Cell-type specific gene activation by c-Myb is achieved via interaction with a number of other transcription factors and multi-protein complexes that determine the function of c-Myb as a regulator of chromatin structure and gene expression downstream of signalling cascades. Mutations that turn c-Myb into a leukaemia gene concomitantly alter the way c-Myb interacts with other proteins. For future consideration of c-Myb or any of its partners as therapeutic targets it will be essential to reveal proteins that it interacts with, their mode of interaction, and the biological consequences of these partnerships.