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New role for the (pro)renin receptor in T cell development

Authors

  • S. Geisberger
  • U. Maschke
  • M. Gebhardt
  • M. Kleinewietfeld
  • A. Manzel
  • R.A. Linker
  • A. Chidgey
  • R. Dechend
  • G. Nguyen
  • O. Daumke
  • D.N. Muller
  • M.D. Wright
  • K.J. Binger

Journal

  • Blood

Citation

  • Blood 126 (4): 504-507

Abstract

  • The (pro)renin receptor (PRR) was originally thought to be important for regulating blood pressure via the renin-angiotensin system. However, it is now emerging that PRR has instead a generic role in cellular development. Here, we have specifically deleted PRR from T cells. T cell-specific PRR-knockout mice had a significant decrease in thymic cellularity, corresponding with a 100-fold decrease in the number of CD4(+) and CD8(+) thymocytes, and a large increase in double negative (DN) precursors. Gene expression analysis on sorted DN3 thymocytes indicated that PRR-deficient thymocytes have perturbations in key cellular pathways essential at the DN3 stage, including transcription and translation. Further characterisation of DN T cell progenitors leads us to propose that PRR deletion affects thymocyte survival and development at multiple stages; from DN3 through to DN4, DP and single positive CD4 and CD8. Our study thus identifies a new role for PRR in T cell development.


DOI

doi:10.1182/blood-2015-03-635292