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The Pediatric Cell Atlas: defining the growth phase of human development at single-cell resolution

Authors

  • D.M. Taylor
  • B.J. Aronow
  • K. Tan
  • K. Bernt
  • N. Salomonis
  • C.S. Greene
  • A. Frolova
  • S.E. Henrickson
  • A. Wells
  • L. Pei
  • J.K. Jaiswal
  • J. Whitsett
  • K.E. Hamilton
  • S.A. MacParland
  • J. Kelsen
  • R.O. Heuckeroth
  • S.S. Potter
  • L.A. Vella
  • N.A. Terry
  • L.R. Ghanem
  • B.C. Kennedy
  • I. Helbig
  • K.E. Sullivan
  • L. Castelo-Soccio
  • A. Kreigstein
  • F. Herse
  • M.C. Nawijn
  • G.H. Koppelman
  • M. Haendel
  • N.L. Harris
  • J.L. Rokita
  • Y. Zhang
  • A. Regev
  • O. Rozenblatt-Rosen
  • J.E. Rood
  • T.L Tickle
  • R. Vento-Tormo
  • S. Alimohamed
  • M. Lek
  • J.C. Mar
  • K.M. Loomes
  • D.M. Barrett
  • P. Uapinyoying
  • A.H. Beggs
  • P.B. Agrawal
  • Y.W. Chen
  • A.B. Muir
  • L.X. Garmire
  • S.B. Snapper
  • J. Nazarian
  • S.H. Seeholzer
  • H. Fazelinia
  • L.N. Singh
  • R.B. Faryabi
  • P. Raman
  • N. Dawany
  • H.M. Xie
  • B. Devkota
  • S.J. Diskin
  • S.A. Anderson
  • E.F. Rappaport
  • W. Peranteau
  • K.A. Wikenheiser-Brokamp
  • S. Teichmann
  • D. Wallace
  • T. Peng
  • Y.Y. Ding
  • M.S. Kim
  • Y. Xing
  • S.W. Kong
  • C.G. Bönnemann
  • K.D. Mandl
  • P.S. White

Journal

  • Developmental Cell

Citation

  • Dev Cell 49 (1): 10-29

Abstract

  • Single-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan.


DOI

doi:10.1016/j.devcel.2019.03.001