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Physical activity during adolescence and risk of colorectal adenoma later in life: results from the Nurses' Health Study II

Authors

  • L.F.M. de Rezende
  • D.H. Lee
  • N.N. Keum
  • K. Nimptsch
  • M. Song
  • I.M. Lee
  • J. Eluf-Neto
  • S. Ogino
  • C. Fuchs
  • J. Meyerhardt
  • A.T. Chan
  • W. Willett
  • E. Giovannucci
  • K. Wu

Journal

  • British Journal of Cancer

Citation

  • Br J Cancer 121 (1): 86-94

Abstract

  • BACKGROUND: Physical activity during adulthood has been consistently associated with lower risk of colorectal cancers, but whether physical activity during adolescence may also play a role in colorectal carcinogenesis is unclear. METHODS: We included 28,250 women in the Nurses' Health Study II who provided data on physical activity during adolescence (ages 12–22 years) in 1997 and underwent lower bowel endoscopy (1998–2011). We used logistic regression models for clustered data to examine the association between physical activity during adolescence and risk of adenoma later in life. RESULTS: Physical activity during adolescence was inversely associated with risk of colorectal adenoma (2373 cases), independent of physical activity during adulthood. The multivariable-adjusted odds ratio (OR) of adenoma was 0.89 (95% CI 0.77–1.02; P(trend) = 0.03) comparing women with ≥ 72 metabolic equivalent of tasks-hours/week (MET-h/week) to < 21 MET-h/week. Women with high physical activity during both adolescence (≥53.3 MET-h/week) and adulthood (≥23.1 MET-h/week) had significantly lower risk of adenoma (all adenomas: OR 0.76; 95% CI 0.66–0.88; advanced adenoma: OR 0.61; 95% CI 0.45–0.82) compared to women with low physical activity during both stages of life. CONCLUSIONS: Our findings suggest that physical activity during adolescence may lower the risk of colorectal adenoma later in life.


DOI

doi:10.1038/s41416-019-0454-1