folder

Polycomb and lung cancer: when the dosage makes the (kind of) poison

Authors

  • G. Gargiulo
  • E. Citterio
  • M. Serresi

Journal

  • Molecular & Cellular Oncology

Citation

  • Mol Cell Oncol 3 (3): e1152345

Abstract

  • The Polycomb transcriptional repressors regulate normal tissue homeostasis and their function is often hijacked during oncogenesis. We recently uncovered the Polycomb repressive complex-2 (PRC2) genes Ezh2 and Eed as oncogenotype-dependent cancer genes. Notably, within the same oncogenotype, PRC2 dosage modulates lung tumor homeostasis and critically impacts non-tumor tissue function.


DOI

doi:10.1080/23723556.2016.1152345