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Propagation of hippocampal ripples to the neocortex by way of a subiculum-retrosplenial pathway

Authors

  • N. Nitzan
  • S. McKenzie
  • P. Beed
  • D.F. English
  • S. Oldani
  • J.J. Tukker
  • G. Buzsáki
  • D. Schmitz

Journal

  • Nature Communications

Citation

  • Nat Commun 11 (1): 1947

Abstract

  • Bouts of high frequency activity known as sharp wave ripples (SPW-Rs) facilitate communication between the hippocampus and neocortex. However, the paths and mechanisms by which SPW-Rs broadcast their content are not well understood. Due to its anatomical positioning, the granular retrosplenial cortex (gRSC) may be a bridge for this hippocampo-cortical dialogue. Using silicon probe recordings in awake, head-fixed mice, we show the existence of SPW-R analogues in gRSC and demonstrate their coupling to hippocampal SPW-Rs. gRSC neurons reliably distinguished different subclasses of hippocampal SPW-Rs according to ensemble activity patterns in CA1. We demonstrate that this coupling is brain state-dependent, and delineate a topographically-organized anatomical pathway via VGlut2-expressing, bursty neurons in the subiculum. Optogenetic stimulation or inhibition of bursty subicular cells induced or reduced responses in superficial gRSC, respectively. These results identify a specific path and underlying mechanisms by which the hippocampus can convey neuronal content to the neocortex during SPW-Rs.


DOI

doi:10.1038/s41467-020-15787-8