Regulation of G0/G1 switch gene 2 (G0S2) expression in human adipose tissue


  • A. Skopp
  • M. May
  • J. Janke
  • H. Kielstein
  • R. Wunder
  • R. Flade-Kuthe
  • A. Kuthe
  • J. Jordan
  • S. Engeli


  • Archives of Physiology and Biochemistry


  • Arch Physiol Biochem 122 (2): 47-53


  • The G0S2 protein attenuated adipose triglyceride lipase activity and decreased lipolysis in rodent and human adipocytes. We hypothesized that G0S2 mRNA expression in human adipose tissue is influenced by depot, adipocyte size, body weight and caloric intake. Adipose tissue samples were obtained during abdominal surgery and by needle biopsy before and 3h after an extended glucose load in lean subjects. G0S2 mRNA was 7x higher expressed in mature human adipocytes compared to the stromavascular fraction. Cell size inversely correlated with G0S2 mRNA expression in both, subcutaneous and omental adipose depots. G0S2 mRNA expression was 75% higher in subcutaneous compared to omental adipose tissue. Obesity was associated with lower G0S2 mRNA expression in subcutaneous adipose tissue. Acute glucose ingestion after an overnight fast did not significantly increase G0S2 expression in subcutaneous adipose tissue. In conclusion, differences in G0S2 expression may explain depot-specific and obesity-associated differences in lipolysis on the molecular level.