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A role for chloride transport in lysosomal protein degradation

Authors

  • L. Wartosch
  • T. Stauber

Journal

  • Autophagy

Citation

  • Autophagy 6 (1): 158-159

Abstract

  • Loss of the lysosomal chloride transport protein ClC-7 leads to complex phenotypes in mice and man, including osteopetrosis, accumulation of lysosomal storage material, and neurodegeneration. Using novel tissue-specific ClC-7 knockout mice, we have shown that upon loss of ClC-7, lysosomal degradation of endocytosed protein is slowed down and accumulation of autophagosomes occurs.


DOI

doi:10.4161/auto.6.1.10590