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Rsp5/Nedd4 clears cells of heat-damaged proteins

Authors

  • T. Sommer
  • A. Weber
  • E. Jarosch

Journal

  • Nature Cell Biology

Citation

  • Nat Cell Biol 16 (12): 1130-1132

Abstract

  • Protein quality control systems protect cells from proteotoxicity caused by the accumulation of aberrantly folded polypeptides. The Rsp5 ubiquitin ligase (mammalian homologue Nedd4) is now identified as a major constituent of a clearance pathway that degrades misfolded cytosolic proteins after exposure to heat.


DOI

doi:10.1038/ncb3079