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SARS-CoV-2 effects on the renin-angiotensin-aldosterone system, therapeutic implications

Authors

  • Q. Ye
  • E.Y. Lai
  • F.C. Luft
  • P.B. Persson
  • J. Mao

Journal

  • Acta Physiologica

Citation

  • Acta Physiol 231 (4): e13608

Abstract

  • Angiotensin converting enzyme-2 (ACE-2) is the cell-surface receptor enabling viral uptake of corona virus 2019 (SARS-CoV-2), thus ACE-2 is a first step towards COVID-19 disease. ACE-2 is a metalloenzyme located primarily on the apical surface, and serves as the entry point also for other coronaviruses, including HCoV-NL63 and SARS-CoV. Throughout evolution, ACE-2 precedes renin, suggesting that ACE-2's role changed over time.


DOI

doi:10.1111/apha.13608