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Tumor rejection by disturbing tumor stroma cell interactions

Authors

  • S. Ibe
  • Z.H. Qin
  • T. Schueler
  • S. Preiss
  • T. Blankenstein

Journal

  • Journal of Experimental Medicine

Citation

  • J Exp Med 194 (11): 1549-1559

Abstract

  • The stroma of solid tumors is a complex network of different cell types. We analyzed stroma cell interactions in two tumor models during cyclophosphamide (Cy)-induced tumor rejection. In growing tumors, tumor infiltrating macrophages (TIMs) produced interleukin (IL)-10. Beginning 6 h after Cy-treatment T cells in the tumor were inactivated and TIMs switched to interferon (IFN)-gamma production. Both, IL-10 production before and IFN-gamma production after Cy-treatment by TIMs required T cells. With the same kinetics as TIMs started to produce IFN-gamma the tumor vasculature was destroyed which required IFN-gamma receptor expression on host but not tumor cells. These events preceded hemorrhagic necrosis and residual tumor cell elimination by T cells. Together, T cells regulate the function of TIMs and tumor rejection can be induced by disturbing the stroma network.


DOI

doi:10.1084/jem.194.11.1549