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Tyrosine-phosphorylated bacterial effector proteins: the enemies within

Authors

  • S. Backert
  • M. Selbach

Journal

  • Trends in Microbiology

Citation

  • Trends Microbiol 13 (10): 476-484

Abstract

  • The tyrosine phosphorylation of proteins has a central role during signal transduction in eukaryotes. Recent progress shows that tyrosine phosphorylation is also a common feature of several effector proteins translocated by bacterial type III and type IV secretion systems. The involvement of these secretion systems in disease development is exemplified by a variety of pathogenic processes: pedestal formation (Tir of EPEC and Citrobacter), cell scattering (CagA of Helicobacter), invasion (Tarp of Chlamydia) and possibly proinflammatory responses and cell proliferation (BepD-F of Bartonella). The discovery that different bacterial pathogens use this common strategy to subvert host-cell function suggests that more examples will soon emerge.


DOI

doi:10.1016/j.tim.2005.08.002