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UnSASPing senescence: unmasking tumor suppression?

Authors

  • C.A. Schmitt

Journal

  • Cancer Cell

Citation

  • Cancer Cell 34 (1): 6-8

Abstract

  • Cellular senescence serves as a barrier to tumor development and a principle effector of anti-cancer therapy, but the largely pro-inflammatory senescence-associated secretory phenotype (SASP) may drive tumor promotion and contribute to age-related pathologies. In this issue of Cancer Cell, Georgilis et al. present SASP-deprived senescence as a potential therapeutic perspective.


DOI

doi:10.1016/j.ccell.2018.06.009