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Vasculitis: a CLEAR argument for targeting complement in ANCA vasculitis

Authors

  • R. Kettritz

Journal

  • Nature Reviews Nephrology

Citation

  • Nat Rev Nephrol 13 (8): 448-450

Abstract

  • Mechanistic studies have implicated the alternative complement pathway, specifically C5a receptor activation, in the pathogenesis of anti-neutrophil cytoplasmic antibody-associated vasculitis. Results from a phase 2 trial suggest that C5a receptor blockade could enable the reduced use or complete withdrawal of steroids from induction protocols.


DOI

doi:10.1038/nrneph.2017.69