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VGLUT2 functions as a differential marker for hippocampal output neurons

Authors

  • C. Wozny
  • P. Beed
  • N. Nitzan
  • Y. Pössnecker
  • B.R. Rost
  • D. Schmitz

Journal

  • Frontiers in Cellular Neuroscience

Citation

  • Front Cell Neurosci 12: 337

Abstract

  • The subiculum is the gatekeeper between the hippocampus and cortical areas. Yet, the lack of a pyramidal cell-specific marker gene has made the analysis of the subicular area very difficult. Here we report that the vesicular-glutamate transporter 2 (VGLUT2) functions as a specific marker gene for subicular burst-firing neurons, and demonstrate that VGLUT2-Cre mice allow for Channelrhodopsin-2 (ChR2)-assisted connectivity analysis.


DOI

doi:10.3389/fncel.2018.00337