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August 03, 2022 in J Med Chem

Structure-based design of xanthine-benzimidazole derivatives as novel and potent tryptophan hydroxylase inhibitors

E. Specker
S. Matthes
R. Wesolowski
A. Schütz
M. Grohmann
N. Alenina
D. Pleimes
K. Mallow
M. Neuenschwander
A. Gogolin
M. Weise
J. Pfeifer
N. Ziebart
U. Heinemann
J.P. von Kries
M. Nazaré
M. Bader

May 15, 2022 in J Mol Biol

An integrated pharmacological, structural, and genetic analysis of extracellular versus intracellular ROS production in neutrophils

C.D. Ellson
I. Goretti Riça
J.S. Kim
Y.M.M. Huang
D. Lim
T. Mitra
A. Hsu
E.X. Wei
C.D. Barrett
L.E. Otterbein
C.J. Hauser
M. Wahl
H. Delbrück
U. Heinemann
H. Oschkinat
C.E.A. Chang
M.B. Yaffe

October 14, 2021 in J Med Chem

Enhanced properties of a benzimidazole benzylpyrazole lysine demethylase inhibitor: mechanism-of-action, binding site analysis, and activity in cellular models of prostate cancer

D.M. Carter
E. Specker
P.H. Malecki
J. Przygodda
K. Dudaniec
M.S. Weiss
U. Heinemann
M. Nazaré
U. Gohlke

August 14, 2021 in Med Genet

Technologies for profiling the impact of genomic variants on transcription factor binding

J. Leiz
M. Rutkiewicz
C. Birchmeier
U. Heinemann
K.M. Schmidt-Ott

June 02, 2021 in Magn Reson

Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling

N. Kamdem
Y. Roske
D. Kovalskyy
M.O. Platonov
O. Balinskyi
A. Kreuchwig
J. Saupe
L. Fang
A. Diehl
P. Schmieder
G. Krause
J. Rademann
U. Heinemann
W. Birchmeier
H. Oschkinat

May 21, 2021 in Nucleic Acids Res

PIN and CCCH Zn-finger domains coordinate RNA targeting in ZC3H12 family endoribonucleases

A. Garg
Y. Roske
S. Yamada
T. Uehata
O. Takeuchi
U. Heinemann

January 07, 2021 in Cancers

Cold-shock domains - abundance, structure, properties, and nucleic-acid binding

U. Heinemann
Y. Roske

January 01, 2021 in J Biol Chem

Pantoea stewartii WceF is a glycan biofilm modifying enzyme with a bacteriophage tailspike-like fold

T. Irmscher
Y. Roske
I. Gayk
V. Dunsing
S. Chiantia
U. Heinemann
S. Barbirz

December 10, 2020 in J Med Chem

From pyrazolones to azaindoles: evolution of active-site SHP2 inhibitors based on scaffold hopping and bioisosteric replacement

Y. Mostinski
G.J.J.E. Heynen
M.P. López-Alberca
J. Paul
S. Miksche
S. Radetzki
D. Schaller
E. Shanina
C. Seyffarth
Y. Kolomeets
N. Ziebart
J. de Schryver
S. Oestreich
M. Neuenschwander
Y. Roske
U. Heinemann
C. Rademacher
A. Volkamer
J.P. von Kries
W. Birchmeier
M. Nazaré

December 01, 2020 in J Dev Biol

Conversion of germ cells to somatic cell types in C. elegans

N. Ul Fatima
B. Tursun