Scientific Publications

Polyglutamine disease proteins: Commonalities and differences in interaction profiles and pathological effects

M. Bonsor
O. Ammar
S. Schnoegl
E.E. Wanker
E. Silva Ramos

AI-guided pipeline for protein-protein interaction drug discovery identifies an SARS-CoV-2 inhibitor

P. Trepte
C. Secker
J. Olivet
J. Blavier
S. Kostova
S.B. Maseko
I. Minia
E. Silva Ramos
P. Cassonnet
S. Golusik
M. Zenkner
S. Beetz
M.J. Liebich
N. Scharek
A. Schutz
M. Sperling
M. Lisurek
Y. Wang
K. Spirohn
T. Hao
M.A. Calderwood
D.E. Hill
M. Landthaler
S.G. Choi
J.C. Twizere
M. Vidal
E.E. Wanker

Cellular senescence: Neither irreversible nor reversible

M. Reimann
S. Lee
C.A. Schmitt

Passenger gene coamplifications create collateral therapeutic vulnerabilities in cancer

Y. Bei
Luca Brame
M. Kirchner
R. Fritsche-Guenther
S. Kunz
A. Bhattacharya
M.C. Rusu
D. Gürgen
F.P.B. Dubois
J.K.C. Köppke
J. Proba
N. Wittstruck
O.A. Sidorova
R. Chamorro González
H. Dorado Garcia
L. Brückner
R. Xu
M. Giurgiu
E. Rodriguez-Fos
Q. Yu
B. Spanjaard
R.P, Koche
C.A. Schmitt
J.H. Schulte
A. Eggert
K. Haase
J. Kirwan
A.I. Hagemann
P. Mertins
J.R. Dörr
A.G. Henssen

LncRNA MIR31HG fosters stemness malignant features of non-small cell lung cancer via H3K4me1- and H3K27Ace-mediated GLI2 expression

W. Chen
F. Wang
X. Yu
J. Qi
H. Dong
B. Cui
Q. Zhang
Y. Wu
J. An
N. Ni
C. Liu
Y. Han
S. Zhang
C.A. Schmitt
J. Deng
Y. Yu
J. Du

November 07, 2023 / Nat Commun

Transcriptional reprogramming by mutated IRF4 in lymphoma

N. Schleussner
P. Cauchy
V. Franke
M. Giefing
O. Fornes
N. Vankadari
S.A. Assi
M. Costanza
M.A. Weniger
A. Akalin
I. Anagnostopoulos
T. Bukur
M.G. Casarotto
F. Damm
O. Daumke
B. Edginton-White
J.C.M. Gebhardt
M. Grau
S. Grunwald
M.L. Hansmann
S. Hartmann
L. Huber
E. Kärgel
S. Lusatis
D. Noerenberg
N. Obier
U. Pannicke
A. Fischer
A. Reisser
A. Rosenwald
K. Schwarz
S. Sundararaj
A. Weilemann
W. Winkler
W. Xu
G. Lenz
K. Rajewsky
W.W. Wasserman
P.N. Cockerill
C. Scheidereit
R. Siebert
R. Küppers
R. Grosschedl
M. Janz
C. Bonifer
S. Mathas

Cox proportional hazards deep neural network identifies peripheral blood complete remission to be at least equivalent to morphologic complete remission in predicting outcomes of patients treated with azacitidine - a prospective cohort study by the AGMT

L. Pleyer
M. Vaisband
M. Drost
M. Pfeilstöcker
R. Stauder
S. Heibl
H. Sill
M. Girschikofsky
M. Stampfl-Mattersberger
A. Pichler
B. Hartmann
A. Petzer
M. Schreder
C.A. Schmitt
S. Vallet
T. Melchardt
A. Zebisch
P. Pichler
N. Zaborsky
S. Machherndl-Spandl
D. Wolf
F. Keil
J. Hasenauer
J. Larcher-Senn
R. Greil

Delineation of functional subdomains of Huntingtin protein and their interaction with HAP40

M.G. Alteen
J.C. Deme
C.P. Alvarez
P. Loppnau
A. Hutchinson
A. Seitova
R. Chandrasekaran
E. Silva Ramos
C. Secker
M. Alqazzaz
E.E. Wanker
S.M. Lea
C.H. Arrowsmith
R.J. Harding

A proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimer's disease

A. Boeddrich
C. Haenig
N. Neuendorf
E. Blanc
A. Ivanov
M. Kirchner
P. Schleumann
I. Bayraktaroğlu
M. Richter
C.M. Molenda
A. Sporbert
M. Zenkner
S. Schnoegl
C. Suenkel
L.S. Schneider
A. Rybak-Wolf
B. Kochnowsky
L.M. Byrne
E.J. Wild
J.E. Nielsen
G. Dittmar
O. Peters
D. Beule
E.E. Wanker

The polyphenol EGCG directly targets intracellular amyloid-β aggregates and promotes their lysosomal degradation

C. Secker
A.Y. Motzny
S. Kostova
A. Buntru
L. Helmecke
L. Reus
R. Steinfort
L. Brusendorf
A. Boddrich
N. Neuendorf
L. Diez
P. Schmieder
A. Schulz
C. Czekelius
E.E. Wanker