Lab coats

Publications

AG Prigione

Mitochondria and the dynamic control of stem cell homeostasis.

Lisowski P, Kannan P, Mlody B, Prigione A.
EMBO rep. 2018 May;19(5). pii: e45432. doi: 10.15252/embr.201745432. Epub 2018 Apr 16. Review.
PMID: 29661859

 

Pluripotent Stem Cells for Uncovering the Role of Mitochondria in Human Brain Function and Dysfunction.

Zink A, Priller J, Prigione A.
J Mol Biol. 2018 Mar 30;430(7):891-903. doi: 10.1016/j.jmb.2018.02.005. Epub 2018 Feb 17. Review.
PMID: 29458125

 

Live-Imaging Readouts and Cell Models for Phenotypic Profiling of Mitochondrial Function.

Iannetti EF, Prigione A, Smeitink JAM, Koopman WJH, Beyrath J, Renkema H.
Front Genet. 2019 Mar 1;10:131. doi: 10.3389/fgene.2019.00131. eCollection 2019.
PMID: 30881379

 

Novel calcineurin A (PPP3CA) variant associated with epilepsy, constitutive enzyme activation and downregulation of protein expression.

Rydzanicz M, Wachowska M, Cook EC, Lisowski P, Kuźniewska B, Szymańska K, Diecke S, Prigione A, Szczałuba K, Szybińska A, Koppolu A, Murcia Pienkowski V, Kosińska J, Wiweger M, Kostrzewa G, Brzozowska M, Domańska-Pakieła D, Jurkiewicz E, Stawiński P, Gromadka A, Zielenkiewicz P, Demkow U, Dziembowska M, Kuźnicki J, Creamer TP, Płoski R.
Eur J Hum Genet. 2019 Jan;27(1):61-69. doi: 10.1038/s41431-018-0254-8. Epub 2018 Sep 25.
PMID: 30254215

 

Mitochondrial metabolism in early neural fate and its relevance for neuronal disease modeling.

Lorenz C, Prigione A.
Curr Opin Cell Biol. 2017 Dec;49:71-76. doi: 10.1016/j.ceb.2017.12.004. Epub 2017 Dec 22. Review.
PMID: 29276950

 

Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a trimeric chaperone complex.

Scior A, Buntru A, Arnsburg K, Ast A, Iburg M, Juenemann K, Pigazzini ML, Mlody B, Puchkov D, Priller J, Wanker EE, Prigione A, Kirstein J.
EMBO J. 2017 Dec 6. pii: e201797212. doi: 10.15252/embj.201797212. [Epub ahead of print]
PMID: 29212816

 

Human mesenchymal factors induce rat hippocampal- and human neural stem cell dependent oligodendrogenesis.

Jadasz JJ, Tepe L, Beyer F, Samper Agrelo I, Akkermann R, Spitzhorn LS, Silva ME, Oreffo ROC, Hartung HP, Prigione A, Rivera FJ, Adjaye J, Küry P.
Glia. 2018 Jan;66(1):145-160. doi: 10.1002/glia.23233. Epub 2017 Sep 22.
PMID: 28940767

 

Concise Review: Induced Pluripotent Stem Cell-Based Drug Discovery for Mitochondrial Disease.

Inak G, Lorenz C, Lisowski P, Zink A, Mlody B, Prigione A.
Stem Cells. 2017 Jul;35(7):1655-1662. doi: 10.1002/stem.2637. Epub 2017 May 22. Review.
PMID: 28544378

 

Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders.

Lorenz C, Lesimple P, Bukowiecki R, Zink A, Inak G, Mlody B, Singh M, Semtner M, Mah N, Auré K, Leong M, Zabiegalov O, Lyras EM, Pfiffer V, Fauler B, Eichhorst J, Wiesner B, Huebner N, Priller J, Mielke T, Meierhofer D, Izsvák Z, Meier JC, Bouillaud F, Adjaye J, Schuelke M, Wanker EE, Lombès A, Prigione A.
Cell Stem Cell. 2017 May 4;20(5):659-674.e9. doi: 10.1016/j.stem.2016.12.013. Epub 2017 Jan 26.
PMID: 28132834

 

A Glycolytic Solution for Pluripotent Stem Cells.

Mlody B, Prigione A.
Cell Stem Cell. 2016 Oct 6;19(4):419-420. doi: 10.1016/j.stem.2016.09.005.
PMID: 27716519

 

Aging vs. rejuvenation: reprogramming to iPSCs does not turn back the clock for somatic mitochondrial DNA mutations.

Lorenz C, Prigione A.
Stem Cell Investig. 2016 Sep 1;3:43. doi: 10.21037/sci.2016.08.09. eCollection 2016. No abstract available.
PMID: 27668250

 

A movement disorder with dystonia and ataxia caused by a mutation in the HIBCH gene.

Schottmann G, Sarpong A, Lorenz C, Weinhold N, Gill E, Teschner L, Ferdinandusse S, Wanders RJ, Prigione A, Schuelke M.
Mov Disord. 2016 Nov;31(11):1733-1739. doi: 10.1002/mds.26704. Epub 2016 Jul 12.
PMID: 27400804

 

A mitochondrial view of cell fate.

Prigione A.
Semin Cell Dev Biol. 2016 Apr;52:66-7. doi: 10.1016/j.semcdb.2016.03.008. No abstract available.
PMID: 27004787

 

Energy metabolism in neuronal/glial induction and in iPSC models of brain disorders.

Mlody B, Lorenz C, Inak G, Prigione A.
Semin Cell Dev Biol. 2016 Apr;52:102-9. doi: 10.1016/j.semcdb.2016.02.018. Epub 2016 Feb 11. Review.
PMID: 26877213

 

Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression.

Wang J, Singh M, Sun C, Besser D, Prigione A, Ivics Z, Hurst LD, Izsvák Z.
Nat Protoc. 2016 Feb;11(2):327-46. doi: 10.1038/nprot.2016.016. Epub 2016 Jan 21.
PMID: 26797457

 

Annexin A1 sustains tumor metabolism and cellular proliferation upon stable loss of HIF1A.

Rohwer N, Bindel F, Grimm C, Lin SJ, Wappler J, Klinger B, Blüthgen N, Du Bois I, Schmeck B, Lehrach H, de Graauw M, Goncalves E, Saez-Rodriguez J, Tan P, Grabsch HI, Prigione A, Kempa S, Cramer T.
Oncotarget. 2016 Feb 9;7(6):6693-710. doi: 10.18632/oncotarget.6793.
PMID: 26760764

 

Erratum: Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer's disease donor as a model for investigating AD-associated gene regulatory networks.

Hossini AM, Megges M, Prigione A, Lichtner B, Toliat MR, Wruck W, Schröter F, Nuernberg P, Kroll H, Makrantonaki E, Zouboulis CC, Adjaye J.
BMC Genomics. 2015 Jun 6;16:433. doi: 10.1186/s12864-015-1537-x. No abstract available.
PMID: 26048372

 

Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer's disease donor as a model for investigating AD-associated gene regulatory networks.

Hossini AM, Megges M, Prigione A, Lichtner B, Toliat MR, Wruck W, Schröter F, Nuernberg P, Kroll H, Makrantonaki E, Zouboulis CC, Adjaye J.
BMC Genomics. 2015 Feb 14;16:84. doi: 10.1186/s12864-015-1262-5. Erratum in: BMC Genomics. 2015;16:433. Zoubouliss, Christos C [corrected to Zouboulis, Christos C].
PMID: 25765079

 

Induced pluripotent stem cells (iPSCs) for modeling mitochondrial DNA disorders.

Prigione A.
Methods Mol Biol. 2015;1265:349-56. doi: 10.1007/978-1-4939-2288-8_24. Review.
PMID: 25634286

 

Assessing the bioenergetic profile of human pluripotent stem cells.

Pfiffer V, Prigione A.
Methods Mol Biol. 2015;1264:279-88. doi: 10.1007/978-1-4939-2257-4_25.
PMID: 25631022

 

Metabolic restructuring and cell fate conversion.

Prigione A, Ruiz-Pérez MV, Bukowiecki R, Adjaye J.
Cell Mol Life Sci. 2015 May;72(9):1759-77. doi: 10.1007/s00018-015-1834-1. Epub 2015 Jan 14. Review.
PMID: 25586562

 

A mitochondrial strategy for safeguarding the reprogrammed genome.

Prigione A, Adjaye J.
Cell Regen (Lond). 2014 Mar 29;3(1):5. doi: 10.1186/2045-9769-3-5. eCollection 2014.
PMID: 25408884

 

Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells.

Wang J, Xie G, Singh M, Ghanbarian AT, Raskó T, Szvetnik A, Cai H, Besser D, Prigione A, Fuchs NV, Schumann GG, Chen W, Lorincz MC, Ivics Z, Hurst LD, Izsvák Z.
Nature. 2014 Dec 18;516(7531):405-9. doi: 10.1038/nature13804. Epub 2014 Oct 15.
PMID: 25317556

 

The return of metabolism: biochemistry and physiology of the pentose phosphate pathway.

Stincone A, Prigione A, Cramer T, Wamelink MM, Campbell K, Cheung E, Olin-Sandoval V, Grüning NM, Krüger A, Tauqeer Alam M, Keller MA, Breitenbach M, Brindle KM, Rabinowitz JD, Ralser M.
Biol Rev Camb Philos Soc. 2015 Aug;90(3):927-63. doi: 10.1111/brv.12140. Epub 2014 Sep 22. Review.
PMID: 25243985

 

Mitochondrial function in pluripotent stem cells and cellular reprogramming.

Bukowiecki R, Adjaye J, Prigione A.
Gerontology. 2014;60(2):174-82. doi: 10.1159/000355050. Epub 2013 Nov 19. Review.
PMID: 24281332

 

HIF1α modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2.

Prigione A, Rohwer N, Hoffmann S, Mlody B, Drews K, Bukowiecki R, Blümlein K, Wanker EE, Ralser M, Cramer T, Adjaye J.
Stem Cells. 2014 Feb;32(2):364-76. doi: 10.1002/stem.1552.
PMID: 24123565

 

Transcriptome based identification of mouse cumulus cell markers that predict the developmental competence of their enclosed antral oocytes.

Vigone G, Merico V, Prigione A, Mulas F, Sacchi L, Gabetta M, Bellazzi R, Redi CA, Mazzini G, Adjaye J, Garagna S, Zuccotti M.
BMC Genomics. 2013 Jun 7;14:380. doi: 10.1186/1471-2164-14-380.
PMID: 23758669

 

OCT4 and the acquisition of oocyte developmental competence during folliculogenesis.

Zuccotti M, Merico V, Belli M, Mulas F, Sacchi L, Zupan B, Redi CA, Prigione A, Adjaye J, Bellazzi R, Garagna S.
Int J Dev Biol. 2012;56(10-12):853-8. doi: 10.1387/ijdb.120174mz. Review.
PMID: 23417407

 

Human induced pluripotent stem cells--from mechanisms to clinical applications.

Drews K, Jozefczuk J, Prigione A, Adjaye J.
J Mol Med (Berl). 2012 Jul;90(7):735-45. doi: 10.1007/s00109-012-0913-0. Epub 2012 May 30. Review.
PMID: 22643868

 

Human stromal (mesenchymal) stem cells from bone marrow, adipose tissue and skin exhibit differences in molecular phenotype and differentiation potential.

Al-Nbaheen M, Vishnubalaji R, Ali D, Bouslimi A, Al-Jassir F, Megges M, Prigione A, Adjaye J, Kassem M, Aldahmash A.
Stem Cell Rev. 2013 Feb;9(1):32-43. doi: 10.1007/s12015-012-9365-8.
PMID: 22529014

 

Teratoma formation of human embryonic stem cells in three-dimensional perfusion culture bioreactors.

Stachelscheid H, Wulf-Goldenberg A, Eckert K, Jensen J, Edsbagge J, Björquist P, Rivero M, Strehl R, Jozefczuk J, Prigione A, Adjaye J, Urbaniak T, Bussmann P, Zeilinger K, Gerlach JC.
J Tissue Eng Regen Med. 2013 Sep;7(9):729-41. doi: 10.1002/term.1467. Epub 2012 Mar 21.
PMID: 22438087

 

Mitochondrial-associated cell death mechanisms are reset to an embryonic-like state in aged donor-derived iPS cells harboring chromosomal aberrations.

Prigione A, Hossini AM, Lichtner B, Serin A, Fauler B, Megges M, Lurz R, Lehrach H, Makrantonaki E, Zouboulis CC, Adjaye J.
PLoS One. 2011;6(11):e27352. doi: 10.1371/journal.pone.0027352. Epub 2011 Nov 14.
PMID: 22110631

 

Molecular insights into reprogramming-initiation events mediated by the OSKM gene regulatory network.

Mah N, Wang Y, Liao MC, Prigione A, Jozefczuk J, Lichtner B, Wolfrum K, Haltmeier M, Flöttmann M, Schaefer M, Hahn A, Mrowka R, Klipp E, Andrade-Navarro MA, Adjaye J.
PLoS One. 2011;6(8):e24351. doi: 10.1371/journal.pone.0024351. Epub 2011 Aug 31.
PMID: 21909390

 

Human induced pluripotent stem cells harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining human embryonic stem cell-like metabolic reprogramming.

Prigione A, Lichtner B, Kuhl H, Struys EA, Wamelink M, Lehrach H, Ralser M, Timmermann B, Adjaye J.
Stem Cells. 2011 Sep;29(9):1338-48. doi: 10.1002/stem.683.
PMID: 21732474

 

Gatekeeper of pluripotency: a common Oct4 transcriptional network operates in mouse eggs and embryonic stem cells.

Zuccotti M, Merico V, Bellone M, Mulas F, Sacchi L, Rebuzzini P, Prigione A, Redi CA, Bellazzi R, Adjaye J, Garagna S.
BMC Genomics. 2011 Jul 5;12:1-13. doi: 10.1186/1471-2164-12-345.
PMID: 21729306

 

Modulation of mitochondrial biogenesis and bioenergetic metabolism upon in vitro and in vivo differentiation of human ES and iPS cells.

Prigione A, Adjaye J.
Int J Dev Biol. 2010;54(11-12):1729-41. doi: 10.1387/ijdb.103198ap.
PMID: 21305470

 

An ES-like pluripotent state in FGF-dependent murine iPS cells.

Di Stefano B, Buecker C, Ungaro F, Prigione A, Chen HH, Welling M, Eijpe M, Mostoslavsky G, Tesar P, Adjaye J, Geijsen N, Broccoli V.
PLoS One. 2010 Dec 30;5(12):e16092. doi: 10.1371/journal.pone.0016092.
PMID: 21209851

 

Comparative analysis of human embryonic stem cell and induced pluripotent stem cell-derived hepatocyte-like cells reveals current drawbacks and possible strategies for improved differentiation.

Jozefczuk J, Prigione A, Chavez L, Adjaye J.
Stem Cells Dev. 2011 Jul;20(7):1259-75. doi: 10.1089/scd.2010.0361. Epub 2011 Jan 24.
PMID: 21162674

 

The LARGE principle of cellular reprogramming: lost, acquired and retained gene expression in foreskin and amniotic fluid-derived human iPS cells.

Wolfrum K, Wang Y, Prigione A, Sperling K, Lehrach H, Adjaye J.
PLoS One. 2010 Oct 29;5(10):e13703. doi: 10.1371/journal.pone.0013703.
PMID: 21060825

 

Alpha-synuclein nitration and autophagy response are induced in peripheral blood cells from patients with Parkinson disease.

Prigione A, Piazza F, Brighina L, Begni B, Galbussera A, Difrancesco JC, Andreoni S, Piolti R, Ferrarese C.
Neurosci Lett. 2010 Jun 14;477(1):6-10. doi: 10.1016/j.neulet.2010.04.022. Epub 2010 Apr 24.
PMID: 20399833

 

A transcriptional roadmap to the induction of pluripotency in somatic cells.

Wang Y, Mah N, Prigione A, Wolfrum K, Andrade-Navarro MA, Adjaye J.
Stem Cell Rev. 2010 Jun;6(2):282-96. doi: 10.1007/s12015-010-9137-2. Review.
PMID: 20336394

 

The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells.

Prigione A, Fauler B, Lurz R, Lehrach H, Adjaye J.
Stem Cells. 2010 Apr;28(4):721-33. doi: 10.1002/stem.404.
PMID: 20201066

 

A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease.

Krüger R, Sharma M, Riess O, Gasser T, Van Broeckhoven C, Theuns J, Aasly J, Annesi G, Bentivoglio AR, Brice A, Djarmati A, Elbaz A, Farrer M, Ferrarese C, Gibson JM, Hadjigeorgiou GM, Hattori N, Ioannidis JP, Jasinska-Myga B, Klein C, Lambert JC, Lesage S, Lin JJ, Lynch T, Mellick GD, de Nigris F, Opala G, Prigione A, Quattrone A, Ross OA, Satake W, Silburn PA, Tan EK, Toda T, Tomiyama H, Wirdefeldt K, Wszolek Z, Xiromerisiou G, Maraganore DM; Genetic Epidemiology of Parkinson's disease consortium.
Neurobiol Aging. 2011 Mar;32(3):548.e9-18. doi: 10.1016/j.neurobiolaging.2009.11.021. Epub 2009 Dec 24.
PMID: 20036034

 

Efficient genetic reprogramming of unmodified somatic neural progenitors uncovers the essential requirement of Oct4 and Klf4.

Di Stefano B, Prigione A, Broccoli V.
Stem Cells Dev. 2009 Jun;18(5):707-16. doi: 10.1089/scd.2008.0180.
PMID: 18724799

 

Lymphomonocyte alpha-synuclein levels in aging and in Parkinson disease.

Brighina L, Prigione A, Begni B, Galbussera A, Andreoni S, Piolti R, Ferrarese C.
Neurobiol Aging. 2010 May;31(5):884-5. doi: 10.1016/j.neurobiolaging.2008.06.010. Epub 2008 Aug 3.
PMID: 18676060

 

Increased oxidative stress in lymphocytes from untreated Parkinson's disease patients.

Prigione A, Isaias IU, Galbussera A, Brighina L, Begni B, Andreoni S, Pezzoli G, Antonini A, Ferrarese C.
Parkinsonism Relat Disord. 2009 May;15(4):327-8. doi: 10.1016/j.parkreldis.2008.05.013. Epub 2008 Jul 21. No abstract available.
PMID: 18640066

 

Mitochondrial DNA deletions induce the adenosine monophosphate-activated protein kinase energy stress pathway and result in decreased secretion of some proteins.

Prigione A, Cortopassi G.
Aging Cell. 2007 Oct;6(5):619-30. Epub 2007 Jul 26.
PMID: 17651460

 

Mitochondrial DNA deletions and chloramphenicol treatment stimulate the autophagic transcript ATG12.

Prigione A, Cortopassi G.
Autophagy. 2007 Jul-Aug;3(4):377-80. Epub 2007 Jul 5.
PMID: 17457038

 

Mitochondrial DNA deletions inhibit proteasomal activity and stimulate an autophagic transcript.

Alemi M, Prigione A, Wong A, Schoenfeld R, DiMauro S, Hirano M, Taroni F, Cortopassi G.
Free Radic Biol Med. 2007 Jan 1;42(1):32-43. Epub 2006 Sep 19.
PMID: 17157191

 

Oxidative stress in peripheral blood mononuclear cells from patients with Parkinson's disease: negative correlation with levodopa dosage.

Prigione A, Begni B, Galbussera A, Beretta S, Brighina L, Garofalo R, Andreoni S, Piolti R, Ferrarese C.
Neurobiol Dis. 2006 Jul;23(1):36-43. Epub 2006 Mar 24.
PMID: 16563783

 

"What do you remember about Chernobyl?" A new test of memory for media-mediated events.

Bizzozero I, Lucchelli F, Prigione A, Saetti MC, Spinnler H.
Neurol Sci. 2004 Oct;25(4):205-15.
PMID: 15549506

 

[Omphalocele and labor].

Chiapponi R, Prigione A, Bailo G, Piacentino A.
Minerva Ginecol. 1988 Nov;40(11):667-70. Italian. No abstract available.
PMID: 3070437