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Sarcomere assembly

Franhziska Rudolph, Thirupugal Govindarajan, Claudia Fink

Overlapping titin molecules form a continuous filament along the muscle fiber. Together with the multiple binding sites for sarcomeric proteins, this makes titin a suitable blueprint for sarcomere assembly. The use of transgenic techniques does not only allow us to address the function of titin’s individual domains in sarcomere assembly, but also to follow sarcomere assembly and disassembly using fluorescently tagged proteins. Understanding the structural and biomechanical functions of titin will help elucidate the pathomechanisms of various cardiovascular diseases and ultimately aid the development of suitable therapeutic strategies.