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ECRC News 2016


August 1, 2016

August 1, 2016

Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing

Three new mutations in patients with congenital heart defects were discovered through the effort of an international consortium including Wellcome Trust Sanger Institute, Competenz Network Congenital Heart Defects, Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK) and the Clinic for Congenital Heart Defects and Pediatric Cardiology of the Christian-Albrechts Universität zu Kiel. The results have been published in Nature Genetics. ECRC researcher and pediatric cardiologist Sabine Klaassen contributed to this work. 


June 7, 2016

Ulrike Stein elected to Metastasis Research Society Board

Group leader Prof. Ulrike Stein of the ECRC has been elected to the Board of the Metastasis Research Society. She will begin her term in autumn of 2016.


 June 2, 2016

Preeclampsia: Inflammation of the placenta interferes with fetal development

Preeclampsia is one of the most common complications to occur during pregnancy, yet its causes are still unknown. A new study involving patients, cell cultures and animal experiments has now shown that those affected by the disease have lower quantities of the placenta’s immune protein CD74, and that certain inflammatory factors are higher. These factors disrupt the formation of the placenta and leave the fetus undernourished.


April 1, 2016

A single roof at Berlin-Buch for scientists, doctors and patients

A joint press release by the Max Delbrück Center for Molecular Medicine (MDC), Charité – Universitätsmedizin Berlin, and the Berlin Institute of Health (BIH)

From 2017, a new building will be constructed on the Berlin-Buch research campus that will unite several institutions under one roof. The Max Delbrück Center for Molecular Medicine (MDC) and Charité – Universitätsmedizin Berlin launched a design competition for a new central site of the Berlin Institute of Health (BIH). The winner has now been chosen, having presented plans for an extension and link building that perfectly reflect the philosophy of the institutions.

March 2, 2016

Jeanette Schulz-Menger becomes President of the global SCMR

Jeanette Schulz-Menger already heads the research group “Cardio-MRT” at the Experimental and Clinical Research Center (ECRC) and the University Clinic for Cardiology on the Charité campus in Buch. In January she acquired yet another prominent position: as President of the Society for Cardiovascular Magnetic Resonance (SCMR), the largest international society bringing together specialists in the field of Cardio-MRT. “This organization combines the expertise of specialists in cardiology and radiology as well as physics, computional science and mathematics and covers both basic research and clinical work,” says Schulz-Menger, who has been active in the society since 1998. She is the first woman to reach the post since the SCMR was founded in 1997.

 February 19, 2016

Precise visualization of myocardial injury

World’s first patient-based cardiac MRI study using 7T MRI



 January 28, 2016

Ischemic renal failure and organ damage: a new mouse model holds the key

Every year acute renal failure affects over 13 million people and leads to 1.7 million deaths across the globe.It often develops when an insufficient supply of oxygen reaches the kidneys, a condition called ischemia. Working with their colleagues from the MDC, the Charité and FMP in Berlin and Hannover Medical School, Dr Lajos Markó and Emilia Vigolo have traced one of the causes of ischemia-related renal failure to a signaling molecule called NF-κB and a specific type of tissue: tubular epithelial cells. Suppressing NF-κB signaling in these renal cells almost entirely eliminates the fatal tissue damage and inflammatory responses that accompany the disease.