Research Highlights

Our research teams publish around 450 specialist articles every year. The MDC research highlights can be found here, presented in a comprehensible format.

Article

Science

Histone H3-tail positioning and acetylation by the c-Myb but not the v-Myb DNA binding SANT domain

The production of blood cells, including erythrocytes, granulocytes, macrophages, and immune cells...
Science

Ubx2 links the Cdc48 complex to ER-associated protein degradation

The secretory pathway of eukaryotic cells harbors an elaborate protein quality control system, which...
Science

A human protein-protein interaction network: the first step towards a human interactome map

The sequencing of the human genome has provided a surprisingly small number of genes, indicating that the complex organization of life is not reflected in the gene number but, rather, in the gene products – that is, in the proteins.
Science

CXCR4 and Gab1 cooperate to control the development of migrating muscle progenitor cells

Cell migration is an important process during development whereby cells are released at defined...
Science

Impaired development of the reproductive organs in mice lacking megalin, an endocytic receptor for steroid hormones

In the circulation, androgens and estrogens are transported by the carrier sex hormone binding...
Science

Oncogene-induced senescence as an initial barrier in lymphoma development

The transformation of a healthy cell into a malignant one is a complicated process. We now know that...
Science

Methyl CpG-binding Proteins Induce Large-scale Chromatin Reorganization During Terminal Differentiation

Pericentric heterochromatin plays an important role in epigenetic gene regulation. In particular...
Science

Requirement of Nuclear Factor-kappaB in Angiotensin II and Isoproterenol-Induced Cardiac Hypertrophy In Vivo

Hypertension is a major public health problem affecting virtually every organ system in the human body and is one of the main causes for enlargement of the heart (cardiac hypertrophy) preceding heart failure.
Science

Impaired Synapse Function during Postnatal Development in the Absence of CALEB, an EGF-like Protein Processed by Neuronal Activity

While humans are born with a complete set of nerve cells, the main development of the connectivity...
Science

The bHLH Factor Olig3 Coordinates the Specification of Dorsal Neurons in the Spinal Cord

Neurons found in the dorsal horn of the spinal cord play a key role in transmitting somatosensory...