Research Highlights | Max Delbrück Center

The research labs of the Max Delbrück Center publish around 450 specialist articles every year. Here you can find our research highlights, presented in a comprehensible way.

Article

Science September 06, 2005

Impaired development of the reproductive organs in mice lacking megalin, an endocytic receptor for steroid hormones

In the circulation, androgens and estrogens are transported by the carrier sex hormone binding...

Science August 15, 2005

Oncogene-induced senescence as an initial barrier in lymphoma development

The transformation of a healthy cell into a malignant one is a complicated process. We now know that...

Science June 20, 2005

Methyl CpG-binding Proteins Induce Large-scale Chromatin Reorganization During Terminal Differentiation

Pericentric heterochromatin plays an important role in epigenetic gene regulation. In particular...

Science May 26, 2005

Requirement of Nuclear Factor-kappaB in Angiotensin II and Isoproterenol-Induced Cardiac Hypertrophy In Vivo

Hypertension is a major public health problem affecting virtually every organ system in the human body and is one of the main causes for enlargement of the heart (cardiac hypertrophy) preceding heart failure.

Science May 21, 2005

Impaired Synapse Function during Postnatal Development in the Absence of CALEB, an EGF-like Protein Processed by Neuronal Activity

While humans are born with a complete set of nerve cells, the main development of the connectivity...

Science March 17, 2005

The bHLH Factor Olig3 Coordinates the Specification of Dorsal Neurons in the Spinal Cord

Neurons found in the dorsal horn of the spinal cord play a key role in transmitting somatosensory...

Science March 02, 2005

Angiotensin II Type 1-Receptor-Activating Antibodies in Renal-Allograft Rejection

Antibody-mediated rejection is thought to account for around one third of all rejections following kidney transplantation.

Science February 14, 2005

Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease

Polygenic diseases present challenges to researchers both in identifying those genes involved as well as in uncovering the complex relationship between gene expression and clinical phenotype.

Science January 06, 2005

LRP2/megalin is required for patterning of the ventral telencephalon

Holoprosencephaly (HPE) is the most common developmental forebrain anomaly in humans and is caused...

Photo reproduced from The Journal of Cell Biology

Science November 10, 2004

Plakophilin 2 is required for normal cardiac development

Plakophilin 2 (PKP2), a member of the armadillo protein family, has been shown to be an essential...