Max Delbrück Center for Molecular Medicine
Cells are made of macromolecules and metabolites that interact to form highly complex networks. Protein-protein, RNA-protein and DNA-protein interactions are critical for the formation of molecular machines, and contribute to global transcriptional networks, positive and negative circuits and other regulatory mechanisms. Macromolecular networks appear to govern all fundamental cellular processes, and perturbations of these networks obviously underlie many human diseases.
Ehrnhoefer DE, Bieschke J, Boeddrich A, Herbst M, Masino L, Lurz R, Engemann S, Pastore A, Wanker EE. EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers. Nat Struct Mol Biol. 2008 Jun;15(6):558-66.
Qi, M-L, Tagawa, K, Enokido, Y, Yoshimura, N, Wada, Y-ichi, Watase, K, Ishiura, S-ichi, Kanazawa, I, Botas, J, Saitoe, M, Wanker, EE and Okazawa, H. (2007). Proteome analysis of soluble nuclear proteins reveals that HMGB 1/2 suppress genotoxic stress in polyglutamine diseases. Nature Cell Biology 9(4), 402-414.
Herbst, M, Wanker, EE. (2007): Small molecule inducers of heat shock response reduce polyQ-mediated huntingtin aggregation. A possible therapeutic strategy. Neurodegener Dis. 4(2-3), 254-60.
Chaurasia G, Iqbal Y, Haenig C, Herzel H, Wanker EE, Futschik ME. (2007). UniHI: an entry gate to the human protein interactome. Nucleic Acids Research, 2007, 35, D590-4.
Ehrnhoefer, DE, Duennwald, M, Markovic, P, Wacker, JL, Engemann, S, Roark, M, Legleiter, J, Marsh, JL, Thompson, LM, Lindquist, S, Muchowski, PJ and Wanker, EE. (2006). Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin- misfolding and reduces toxicity in Huntington’s disease models. Hum Mol Genet. 15(18), 2743-2751.