Tursun Group Research

Tursun Lab

Gene Regulation and Cell Fate Decision in C. elegans

Profile

Understanding mechanisms which safeguard cellular identities is key to improving the reprogramming of differentiated cells.

Lab website: Tursunlab.org

Understanding the mechanisms that safeguard cellular identities is key to improving cell fate reprogramming and has great biological and medical importance for prospective tissue replacement therapies.

We are using the Nematode Caenorhabditis elegans (C. elegans) as a powerful genetic model organism to study cellular reprogramming. The mission of our lab is to genetically identify and characterize factors that form a barrier for transcription factor-induced cellular reprogramming. Building on successful validation of chromatin regulators acting as reprogramming barriers in C. elegans as well as Human, we continue to study whether more of our newly identified factors have conserved functions.

Strikingly, a number of our identified barrier factors are implicated in Aging regulation suggesting a link between safeguarding cell fates, cellular homeostasis and the control of lifespan.

Based on the large number of homologous genes among C. elegans and Humans our research reveals conserved mechanisms that act as barriers to cellular reprogramming and play important roles during Aging and tissue homeostasis.

To learn more about the Tursun Research Group please visit our lab website: Tursunlab.org

Team

Publications

News

Dr. Baris Tursun
Dr. Baris Tursun
Group Leader
Contact
Max-Delbrück-Center for Molecular Medicine in the Helmholtz-Association
Berlin-Mitte (BIMSB)
Hannoversche Str. 28
10115 Berlin
 
Building 101, Room 2.06
 
(030) 9406 1730
 
Secretariat
 
Regina Philipp
 
Berlin-Mitte (BIMSB)
Building 101, Room 1.02
 
(030) 9406 1770