We use Caenorhabditis elegans as a genetic model organism to systematically study the molecular basis of cell fate maintenance and protection. C. elegans provides genetic tractability and visualization of cell conversions in vivo.
We utilized large-scale genetic screens to identify factors safeguarding cell fates and acting as a barrier for direct conversion of cells to a different identity (Transdifferentiation / Direct Reprogramming). Additionally, we are studying the interconnection of Aging and Cellular Reprogramming.
Our findings could help overcome the limitations of Direct Reprogramming in order to generate the cellular material for prospective tissue replacement therapies.
To learn more about the Tursun Research Group please visit our lab website: