Kühn Lab

Specifically we are running projects to:

• build new disease models in mice and human iPS cells
• approach gene therapy in mouse models and patient-derived cells
• explore exon replacement by NHEJ for gene repair and humanisation
• operate the core facility for mouse genome engineering
• pursue genome repair to optimize the C57BL/6 inbred mouse strain

Genome engineering is a key technology to study gene function in health and disease. The continuous innovation of gene editing technologies is the base for the next generation of biomedical research.

_{*Nucleic Acid Sequence Replacement by NHEJ. PCT International Publication Number: WO 2019/122302 A1 (2019).}