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The Max Delbrück Center for Molecular Medicine carries out basic biomedical research. We try to understand the causes of diseases at the molecular level, in order to better diagnose, treat and prevent them. Our aim is to transfer our findings as quickly as possible into practical applications.

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Research Highlights

A cool new method for growing better muscle

Satellite cells, which develop into striated muscle, have a regenerative capacity which could be useful in therapies for muscular dystrophy and other diseases. The groups of Simone Spuler and Zsuzsanna Izsvák have now developed a method to isolate human satellite cells and equip them with new genes. The work appeared in the Oct. 1 edition of the Journal of Clinical Investigation.

The river that shapes the heart

The mechanisms that control and coordinate the development of the chambers of the heart have been a mystery. Now a recent study by Salim Seyfried’s group, published in the August issue of Developmental Cell, shows that the development of cardiac structure is linked to the beginning of blood flow during early embryonic development. This affects molecular signals in the inner tissue, called the endocardium, and guides the construction of heart chambers of different sizes.