The MDC Mission

The Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) carries out basic biomedical research with the aim of understanding the molecular basis of health and disease, and translating these findings as quickly as possible into clinical application. The research involves the diagnosis and treatment of diseases, as well as their prevention.

Research Highlights

New brick in PKA Legoland adds complexity to a picture we thought we knew well

Protein Kinase A (PKA) is a protein that enjoys enough fame to be sketched by young biochemists listening to lectures about how it is regulated. The fundamental kinase is present throughout the body with a role in countless processes. It's easy to think PKA is so well studied that we know everything about it, but scientists at the MDC have found a new layer of PKA regulation which was published this week in Nature Communications.


The life cycle of proteins

Some proteins behave in an unusual way: the older they become, the more stable they are. A research team at the MDC has now published this surprising finding in the journal Cell. Their work has traced the life cycle of thousands of proteins from synthesis to disposal. The results are relevant for diseases where there are surplus copies of certain genes.


Further research highlights


How the naked mole-rat escapes inflammatory pain

In injuries and inflammation, naked mole-rats do not develop normal hypersensitivity to temperature stimuli. This is due to a tiny change in a receptor molecule on cells called TrkA, as a research team from the MDC has now discovered. The work, which appears in the journal Cell Reports, may be important for pain therapy in humans.


MDC researchers discover new regulatory mechanism of important protein

Protein kinase A is an important signaling enzyme that is found throughout the body and is involved in many cellular processes. It was thought to have been comprehensively studied, but scientists at the MDC have now discovered a new layer of PKA regulation.


Governing Mayor Michael Müller visits Berlin-Buch campus

On October 5, 2016, Governing Mayor of Berlin Michael Müller paid a visit to the MDC and the Berlin-Buch campus.


Further news on MDC Insights