circRNAs (zirkuläre RNAs) in neuralen Zellen

Understanding the molecular basis of health and disease

Technology Platform Flow Cytometry

Innovating medical therapies and clinical diagnostics

Technology Platform Bioinformatics

Developing game changing methods and technologies

MDC_Juli_2017_5615.jpg

Supporting scientific education and career development

Research at the MDC

Research at the MDC aims to elucidate the molecular mechanisms of health and disease, and translate those findings into medical practice.

Research

Research Teams

Our independent research teams pursue their research in Cardiovascular and Metabolic Disease, Cancer Research, Diseases of the Nervous System, and Medical Systems Biology.

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Discover our research groups
Jonathan Alles und Angela Merkel

New research building in Berlin Mitte

With a clear commitment to research and health science, Chancellor Angela Merkel opened the new MDC research building for the Berlin Institute for Molecular Systems Biology.

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Explore our new building
induced pluripotent stem cells in a pluripotency test

Research News & Events

Breaking_Boundaries_09_09_2019_4271
Institute & Campus

“We need to show solidarity with the Friday strikes by schoolchildren!”

Exactly 30 years after the founding of the Neues Forum, Jens Reich has called upon researchers to once again get involved in the political discourse. The full text of his speech can be found below. Reich’s speech and a concert by Wolf and Pamela Biermann kicked off a new event series, entitled “Breaking Boundaries,” at MDC Berlin-Mitte/BIMSB.
Berlin Summer Meeting 2019
Science

Countdown to the Berlin Summer Meeting

Big data and machine learning are the focus of this year’s Berlin Summer Meeting, which will be held in September at the Berlin Institute for Medical Systems Biology (BIMSB). International speakers will explore the opportunities and limits of artificial intelligence.
EMBO workshop Beyond the standard
Science

EMBO Workshop: Move over, mouse!

Researchers from more than 20 countries are gathering in Berlin to share their experiences working with “non-model organisms”, such as pythons, Tasmanian devils and naked mole rats.
Science

The link between gut bacteria and blood pressure

A new research group led by Dr. Nicola Wilck is investigating the influence of the gut microbiome on high blood pressure. The European Research Council (ERC) is funding the project with an ERC Starting Grant of €1.5 million over five years.
Jane Reznick

Research for a long life

Learning from naked mole-rats is key to Jane Reznick’s research into new therapies for heart disease and strokes. She has now been awarded an ERC Starting Grant, which will help her to start her own group and fund her work to the tune of €1.55 million over five years.
Karl Max Einhäupl

MDC bids farewell to Charité’s head Karl Max Einhäupl and welcomes his successor Heyo Kroemer, lauding fair collaboration

As Karl Max Einhäupl steps down as Chairman of the Charité’s Executive Board, Thomas Sommer, interim Scientific Director of the MDC, honors Einhäupl’s achievements and applauds him for the excellent and equitable collaboration. Sommer wishes the Charité’s new head, Heyo Kroemer, the very best and much success in his new position.
Sequenzierung der Booten-RNA und ihrer Enden
Science

FLAM-seq: the full picture of messenger RNA and their tails

Researchers at the Max Delbrück Center for Molecular Medicine (MDC) have developed a method enabling the complete sequence of messenger RNA molecules including their unique ends, which are called poly(A) tails.
Preibisch Paper 08/19

Google Maps for tissues

Modern light microscopic techniques provide extremely detailed insights into organs, but the terabytes of data they produce are usually nearly impossible to process. New software, developed by a team led by MDC scientist Dr. Stephan Preibisch and now presented in Nature Methods, is helping researchers make sense of these reams of data.
Hochauflösende mikroskopische Aufnahme einer einzelnen Herzmuskelzelle in welcher ein herzmuskelspezifisches Gen (TNNT2) sowie eine spezifische Kernfärbung zu sehen ist.
Science

How a mutation harms the heart

What does a protein forming the cell’s nuclear envelope have to do with a dangerous heart condition? Aided by stem cell experiments, a team of researchers from Stanford University and the MDC recently answered this question.
Berlin Skyline

Thomas Sommer (MDC) congratulates Berlin University Alliance on winning the Excellence Competition

The Berlin University Alliance has won the Excellence Competition. Thomas Sommer, Scientific Director (interim) of the MDC) congratulated the alliance, which includes three Berlin universities and Charité University Hospital.
PM Daumke Mitochondrien

Keeping a cell’s powerhouse in shape

A German-Swiss team around Professor Oliver Daumke from the MDC has investigated how a protein of the dynamin family deforms the inner mitochondrial membrane. The results, which also shed light on a hereditary disease of the optic nerve, have been published in Nature.
Genomics Platform

We are looking forward to the partnership with the BIH

The administrative agreement is signed, the Berlin Institute of Health ( BIH ) will become the third pillar of the Charité. "We are excited about the privileged partnership," says Professor Thomas Sommer, interim Scientific Director of the MDC.
Nashornkühe Fatu und Najin
Science

Rhinos from skin cells

With its large-scale research project BioRescue, the German Federal Ministry of Education and Research (BMBF) is funding research into the artificial reproduction of the functionally extinct northern white rhino. MDC researchers are among the project partners working together to create new animals from skin cells.
human cardiomyocytes that were derived from induced pluripotent stem cells

Straight to the heart

An international team of researchers are seeking to explore the heart at a depth that was previously impossible. They have now received a grant of nearly four million US dollars from the Chan Zuckerberg Initiative – as one of the 38 Seed Networks working on the Human Cell Atlas. MDC researcher Norbert Hübner is co-coordinator of the project.

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Publications

Angiotensin II type 2 receptor mediates high fat diet-induced cardiomyocyte hypertrophy and hypercholesterolemia

Mol Cell Endocrinol

Cardiorenal (23)Na MRI at 7.0 Tesla using a 4/4 channel (1)H/(23)Na RF antenna array

Magn Reson Med

Strategies for in vivo reprogramming

Curr Opin Cell Biol

HIF1A and NFAT5 coordinate Na(+)-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting

Autophagy

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