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The Max Delbrück Center for Molecular Medicine carries out basic biomedical research. We try to understand the causes of diseases at the molecular level, in order to better diagnose, treat and prevent them. Our aim is to transfer our findings as quickly as possible into practical applications.

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Research Highlights

Juggling molecules while balancing the brain

Our brains usually maintain an overall balance that is disrupted in diseases such as epilepsy. Jochen Meier’s lab has now linked a specific form of the glycine receptor, a protein involved in neurotransmission, to imbalances in communication between brain cells. The work appears in a recent edition of the Journal of Clinical Investigation.

Showing defective proteins the door

Some proteins are misfolded during their processing in a cellular structure called the endoplasmic reticulum. In the Jan. 16 issue of Nature Cell Biology, Thomas Sommer’s group identifies a molecule that plays a key role in transporting them to the cytoplasm, where they will be destroyed.