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In Berlin, Prof. Hebebrand gave some examples to illustrate his hypothesis about the effect of...

With respect to the development of T-cells, Dr. Rosenbauer and colleagues could also show that the...

Such cells control aggressive immune cells and, thus, unwanted immune reactions by the graft can be...

How does a cell manage to identify and degrade the diverse types of defective proteins and thus protect the body against serious diseases? The researchers Sabine C. Horn, Professor Thomas Sommer, Professor Udo Heinemann and Dr. Ernst Jarosch of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch, Germany, have now found a crucial piece in this puzzle. In an enzyme complex that plays a critical role in the quality control of proteins, they discovered a scaffold regulating the identification and disposal of various defectively produced proteins. (Molecular Cell, doi: 10.1016/j.molcel200910.015)*.

Two researchers of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch will receive more than 3 million euros in research funding from the European Research Council (ERC) in Strasbourg. Cancer researcher Dr. Michela Di Virgilio and systems biologist Dr. Baris Tursun of the Berlin Institute for Medical Systems Biology (BIMSB) of the MDC will receive an ERC Starting Grant endowed with 1.9 million euros and 1.5 million euros respectively.

In the News and Views column of the journal (p. 723), Richard Warn from the School of Biological...

The American immunologist Dr. William E. Paul has received the Max Delbrück Medal in Berlin. The jury honored the researcher for his work on a key regulator of the immune system, interleukin 4 (IL-4). Dr. Paul works at the National Institute of Allergy and Infectious Diseases (NIAID) at the National Institutes of Health (NIH) in Bethesda, Maryland, USA. Professor Andreas Radbruch, scientific director of the German Rheuma Research Center Berlin, held the laudatory address.

The study focused on the formation of cellular rosettes within an epithelial tissue and their...

The substance EGCG (Epigallocatechin-3-gallate) from green tea can redirect the deadly process which leads to the accumulation of protein aggregates in Parkinson`s and Alzheimer`s disease. EGCG modulates a cascade of protein misfolding in such a way that the formation of deadly plaques is interrupted, and harmless protein structures emerge instead.