Scientific Publications Search Search Author Impact Factor Release Date Research Group Search Sort by RelevanceFrom A-ZAuthored onDate/Time RangeRelease date Order AscDesc Acevedo Ochoa, Ernesto (1) Adami, Eleonora Dr. (5) Akalin, Altuna Dr. (6) Akmeric, Emir Bora (2) Alenina, Natalia Dr. (8) Altmueller, Janine Dr.med. (36) Anandakumar, Harithaa (1) Annibale, Paolo Dr. (5) Arnau Soler, Aleix Dr. (2) Bader, Michael Prof. Dr. (22) Bahr, Lina Samira Dr. (2) Bähring, Sylvia Dr. (1) Bahry, Ella Dr. (2) Barke, Niclas (1) Bartels-Klein, Eireen (2) Bartolomaeus, Hendrik (3) Bartolomaeus, Theda (4) Baumann, Elisabeth (1) Bayram, Safak (1) Begay-Müller, Valerie Dr. (3) Berangi, Mostafa (2) Bernert, Carola (1) Beule, Dieter Dr. (20) Birchmeier, Walter Prof. Dr. (3) Birchmeier-Kohler, Carmen Prof. Dr. (2) Birkner, Till (3) Birol, Melissa Dr. (1) Blachut, Susanne (1) Blankenstein, Thomas Prof. Dr. (6) Blume, Alexander Dr. (2) Blüthgen, Nils (3) Bock-Bierbaum, Tobias Dr. (1) Borodina, Tatiana Dr. (4) Braeuning, Caroline (1) Brüning, Ulrike Dr. (3) Bunse, Mario Dr. (4) Cakmak-Görür, Nese Dr. (1) Carvalho, Silvia Filipa (1) Cerda Jara, Cledi Alicia (1) Chekulaeva, Marina Dr. (1) Chen, Chia-Yu (1) Chen, Wei Prof. Dr. (1) Cibin, Penelope (1) Clauß, Julian (1) Collins, Russell Thomas Dr. (2) Conrad, Thomas Dr. (3) Coscia, Fabian Dr. (6) Crocini, Claudia Dr. (1) Dahlmann, Mathias Dr. (7) Dartsch, Josephine (1) Daumke, Oliver Prof. Dr. (6) Dechend, Ralf Priv. Doz. (11) de la Rosa, Kathrin Prof. Dr. (3) Del Giudice, Simone (1) Deter, Aylina (1) Diecke, Sebastian Dr. (13) Dietrich, Carola (1) Di Virgilio, Michela Prof. Dr. (2) Dräger, Alexander (1) Edes, Inan Dr. (1) Eisenberger, Alina (1) Emmenegger, Lisa (1) Endemann, Beate Dr. (1) Escobar Fernandez, Helena Dr. (4) Essex, Morgan (1) Falcke, Martin Prof. Dr. (2) Faxel, Miriam (1) Feinkohl, Insa Prof. Dr. (5) Fernández Ochoa, Álvaro Dr. (5) Fielitz, Jens Dr. (5) Filosa, Alessandro Dr. (2) Fischer, Cornelius Dr. (5) Forbes, Martin Dr. (1) Forslund, Sofia Dr. (16) Frahm, Silke Dr. (3) Franke, Vedran Dr. (4) Freimuth, Jonas (1) Friedrich, Corinna (1) Fritsche, Raphaela Dr. (4) Garcia Contreras, Jonathan Alexis (1) Gargiulo, Gaetano Dr. (1) Geisberger, Sabrina Yasmin Dr. (3) Genehr, Carolin (1) Gerhardt, Holger Prof. Dr. (9) Gerlach, Kerstin (2) Ghanbari, Mahsa Dr. (2) Ghauri, Ahla (3) Giese, Wolfgang Dr. (2) Gil, Marine (1) Gladytz, Thomas (1) Glorani, Giulia Dr. (1) Gotthardt, Michael Prof. Dr. (5) Gouti, Mina Dr. (3) Graf, Robin Dr. (1) Greensmith, Robert (1) Guarino, Vanessa Emanuela (2) Guignard, Leo Dr. (1) Gutmann, Friederike (2) Haas, Simon Dr. rer. nat. (7) Haase, Nadine Dr. (2) Haghverdi, Laleh Dr. (2) Hammes-Lewin, Annette Dr. (2) Hartl, Kimberly (1) Haucke, Volker Professor (2) Heinemann, Udo Prof. Dr. (2) Henssen, Anton Prof. Dr. med. (11) Herse, Florian PD Dr. (2) Heuser, Arnd Dr. (2) Hinze, Christian Dr. med. Dipl.-Math. (5) Hirsekorn, Antje (1) Hofer, Sebastian Dr. (2) Höpken, Uta Elisabeth PD Dr. (9) Hörnberg, Hanna Dr. (1) Hübner, Norbert Prof. Dr. (15) Huppa, Johannes Prof. (4) Infante Duarte, Carmen (9) Ivics, Zoltan Dr. (2) Izsvak, Zsuzsanna Dr. (8) Jäger, Marten Dr. (1) Janke, Jürgen Dr. (3) Janz, Martin Dr. (4) Jarquin Diaz, Victor Hugo Dr. (1) Jeanrenaud, Alexander Carlin (2) Jedamzick, Johanna Verena (1) Jentsch, Thomas Prof. Dr. (3) Jung, Simone (1) Junker, Jan Philipp Prof. Dr. (5) Kainmüller, Dagmar Prof. Dr. (6) Kaminski, Michael Dr. (2) Kammertöns, Thomas Dr. (2) Kaufmann, Tom (1) Kautz, Pauline (1) Kempa, Stefan Dr. (6) Kettenmann, Helmut Prof. Dr. (4) Kettritz, Ralph Prof. Dr. (6) Kieshauer, Janine (1) Kirchner, Marieluise Dr. (9) Kirwan, Jennifer Dr. (9) Klaassen, Sabine Prof. Dr. med. (11) Klaus-Bergmann, Alexandra Dr. (1) Klich, Jasmin Daniela (1) Klußmann, Enno PD Dr. (5) Kobelt, Dennis Dr. (13) Kocks, Christine Dr. (2) Köhler, May-Britt (1) Kolesnichenko, Marina Dr. (2) Kräker, Kristin Dr. (2) Krüger, Kerstin (1) Krüger, Norman (1) Krull, Sandra Dr. (1) Kudryashev, Mikhail Prof. Dr. (2) Kühn, Ralf Dr. (8) Kukalev, Alexander Dr. (1) Kunz, Severine Dr. (3) Lacadie, Scott Allen Dr. (2) Landthaler, Markus Prof. Dr. (14) Langanki, Reika (1) Lebedin, Mikhail (2) Lee, Young-Ae Prof. Dr. (6) Leisegang, Matthias Prof. Dr. rer. nat. (2) Leutz, Achim Prof. Dr. (4) Lewin, Gary Prof. Dr. (6) Lindberg, Eric Lars-Helge (3) Lisek, Kamil Dr. (1) Lisowski, Pawel Dr. (3) Liu, Tiannan (1) Löber, Ulrike Dr. (6) Lohse, Martin Prof. Dr. (7) Lorenz, Felix Dr. (1) Ludwig, Leif S. Dr. med. Dr. rer. nat. (6) Luft, Friedrich Prof. Dr. (11) Mahmoodzadeh, Shokoufeh PD Dr. (1) Mais, Lisa (1) Marenholz, Ingo Dr. (2) Marg, Andreas Dr. (2) Marko, Lajos Dr. (8) Marot-Lassauzaie, Valérie (1) Maschmeyer, Patrick Dr. (1) Mathas, Stephan Dr. (4) Meier, Katja (2) Merks, Anne Margarete Dr. (1) Mertins, Philipp Dr. (18) Metzger, Jakob Johannes Dr. (1) Meyer, Irmtraud Margret Prof. Dr. (2) Millward, Jason Dr. (2) Minia, Igor Dr. (1) Mintcheva, Janita (1) Monti, Remo (1) Moreno Velásquez, Ilais Dr. (4) Motta, Edyta Maria (1) Müller, Dominik Prof. Dr. (9) Müthel, Stefanie (2) Na, Il-Kang Dr. (8) Napieczynska, Hanna Dr. (1) Nazare, Marc (2) Neuschulz, Anika (1) Niendorf, Thoralf Prof. Dr. (11) Nimptsch, Katharina Dr. (9) Noel, Jeffrey Dr. (3) Nolte, Christiane Dr. (1) Nurzed, Bilguun (1) Obermayer-Wasserscheid, Benedikt Dr. (11) Oertel, Frederike Cosima MD/PhD (11) Ohler, Uwe Prof. Dr. (14) Olivares Chauvet, Pedro Dr. (1) Oliveras Martinez, Anna Dr. (3) Panakova, Daniela Dr. (5) Pande, Amit Dr. (1) Patarcic, Inga Dr. (1) Patone, Giannino Dr. (4) Paul, Friedemann Prof. Dr. med. (65) Perovic, Tijana (1) Perrot, Andreas (1) Pezzutto, Antonio Prof. Dr. (3) Pham, Thu Thi Dr. (1) Pischon, Tobias Prof. Dr. (22) Pohl, Tobias Dr. (1) Polovitskaya, Mayya (1) Pombo, Ana Prof. Dr. (4) Popova, Elena Dr. (1) Popp, Oliver Dr. (8) Potapenko, Olena (1) Potente, Michael Prof. Dr. (5) Preibisch, Stephan Dr. (5) Prigione, Alessandro Prof. Dr. (4) Qadri, Fatimunnisa Dr. (3) Quedenau, Claudia (3) Rahimi, Faezeh (2) Rahn, Hans-Peter Dr. (1) Rajewsky, Klaus Prof. Dr. (6) Rajewsky, Nikolaus Prof. Dr. (12) Rautenstrauch, Pia Josefine (2) Rehm, Armin Dr. (7) Rhein, Simone Dr. (2) Robson, Michael Dr. (3) Röefzaad, Claudia (1) Roman, Alexandra (1) Rosenberger, Leonie Milena (1) Rosillo Salazar, Oscar Daniel (1) Roske, Yvette Dr. (1) Rousselle, Anthony (2) Ruiz Orera, Jorge Dr. (6) Rumberger, Josef Lorenz (2) Rybak-Wolf, Agnieszka Dr. (1) Saar, Kathrin Dr. (3) Saha, Nandita (1) Sai, Somesh (1) Sander, Maike Prof. Dr. (8) Sanders, Ashley Dr. (6) Santuz, Alessandro Dr. (1) Sapozhnikova, Valeriia (1) Sattentau, Quentin James Prof. Dr. (6) Sauve, Ilaria (1) Sawamiphak, Suphansa Dr. (2) Schäfer, Ronny (1) Scheidereit, Claus Prof. Dr. (2) Schiattarella, Gabriele G. Dr. (6) Schmidt, Deborah (1) Schmitt, Clemens Prof. Dr. (10) Schmitt, Matthias Jürgen Dr. (1) Schreiber, Adrian PD Dr. med. (4) Schulz-Menger, Jeanette Prof. Dr. (20) Schütz, Anja Dr. (1) Schwarz, Roland Dr. (2) Schwedhelm, Carolina Dr. (3) Seidel, Franziska Dr. med. (6) Selbach, Matthias Prof. Dr. (10) Shih, Alexis Zi Le Dr. (1) Sholokh, Anastasiia (1) Shvetsov, Nikolay (1) Sigal, Michael Dr. (7) Simon, Katja Prof. Dr. (8) Simon, Mareike Dr. (1) Smith, Janice (1) Sohail, Iqra (1) Sohn, Madlen (1) Sommer, Thomas Prof. Dr. (1) Specker, Edgar Dr. (1) Sporbert, Anje Dr. (4) Sprink, Thiemo Dr. (1) Spuler, Simone Prof. (12) Stadelmann, Christian (1) Starke, Ludger Benedikt (1) Stein, Ulrike Prof. Dr. (16) Steinfelder, Svenja Dr. (1) Strzelecka, Paulina Maria (1) Suarez Artiles, Lorena Dr. (1) Sugimoto, Yoichiro Dr. (3) Sunaga-Franze, Daniele Yumi Dr. (2) Szabo, Dominik (1) Taube, Martin (1) Teixeira Alves, Luiz Gustavo Dr. (4) Telugu, Narasimha Swamy Dr. (6) Thieme, Christoph Dr. (1) Torke, Sebastian Dr. (1) Tsybulskyi, Volodymyr (1) Tursun, Baris Dr. (2) Uckert, Wolfgang Prof. Dr. (1) Uyar, Bora Dr. (3) Vazquez Garcia, Clara (1) Vazquez Sarandeses, Elena (1) Veltsista, Paraskevi Danai (1) Vidal, Marie Dr. (1) Vieira da Silva, Rafaela (4) Villamil, Gabriel (1) von Kries, Jens Peter Dr. (4) Vucicevic, Dubravka (1) Waiczies, Sonia PD Dr. (1) Wallukat, Gerd Dr. (2) Walther, Wolfgang Prof. Dr. (14) Wanker, Erich Prof. Dr. (3) Weidner, Patrick (1) Wendlinger, Sarah (1) Wesolowski, Radoslaw Dr. (1) Wilck, Nicola Dr. med. (5) Willimsky, Gerald Dr. (3) Willnow, Thomas Prof. Dr. (1) Winick-Ng, Warren Dr. (1) Wirges, Anthea Dr. (2) Woehler, Andrew Dr. (4) Wolf, Jana Prof. Dr. (2) Wolf, Susanne Dr. (2) Wurmus, Ricardo (2) Wyler, Emanuel Dr. (15) Yousefian, Schayan (2) Yu, Xiaoyan (1) Zampieri, Niccolo Dr. (5) Zauber, Henrik Dr. (1) Zea Redondo, Luna (1) Ziehm, Matthias Dr. (1) Zimmermann, Karin Dr. (2) Zinzen, Robert Patrick Dr. (1) Zong, Yue Dr. (1) Zühlke, Kerstin Dr. (2) Zywitza, Vera Dr. (3) (-) Chu, Van Trung Dr. (2) (-) Lupianez Garcia, Dario Jesus Dr. (4) (-) Maatz, Henrike Dr. (3) (-) Mastrobuoni, Guido Dr. (3) 2006 (1) 2007 (3) 2008 (1) 2009 (2) 2010 (1) 2011 (5) 2012 (5) 2013 (6) 2014 (2) 2015 (8) 2016 (7) 2017 (8) 2018 (7) 2019 (13) 2021 (5) (-) 2022 (12) 2023 (10) 2024 (9) Bioinformatics and Omics Data Science (1) Genetics and Genomics of Cardiovascular Diseases (3) Genome Engineering & Disease Models (2) Immune Mechanisms and Human Antibodies (1) Immune Regulation and Cancer (2) Microenvironmental Regulation in Autoimmunity and Cancer (1) Molecular Genetics of Chronic Inflammation and Allergic Disease (1) Organoids (1) Proteome Dynamics (1) Proteomics and Metabolomics (3) RNA Biology and Posttranscriptional Regulation (1) Systems Biology Imaging (2) Systems Biology of Gene Regulatory Elements (1) Transgenics (2) Translational Bioinformatics (1) 12 Results: Active Filter: Chu, Van Trung Dr.Lupianez Garcia, Dario Jesus Dr.Maatz, Henrike Dr.Mastrobuoni, Guido Dr.2022 Sort: Result score Newest to oldest Oldest to newest February 09, 2022 / bioRxiv Spatio-temporal, optogenetic control of gene expression in organoids I. Legnini L. Emmenegger A. Zappulo R. Wurmus A. Oliveras Martinez C. Cerda Jara A. Boltengagen T. Hessler G. Mastrobuoni A. Rybak-Wolf S. Kempa R.P. Zinzen A. Woehler N. Rajewsky March 22, 2022 / bioRxiv The little skate genome and the evolutionary emergence of wing-like fin appendages F. Marletaz E. de la Calle-Mustienes R.D. Acemel T. Nakamura C. Paliou S. Naranjo P.M. Martinez-Garcia I. Cases V.A. Sleight C. Hirschberger M. Marcet-Houben D. Navon A. Andrescavage K. Skvortsova P.E. Duckett A. Gonzalez-Rajal O. Bogdanovic J.H. Gibcus L. Yang L. Gallardo-Fuentes I. Sospedra J. Lopez-Rios F. Darbellay A. Visel J. Dekker N. Shubin T. Gabaldon J.J. Tena D.G. Lupianez D.S. Rokhsar J.L. Gomez-Skarmeta August 05, 2022 / Science Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies D. Reichart E.L. Lindberg H. Maatz A.M.A. Miranda A. Viveiros N. Shvetsov A. Gärtner E.R. Nadelmann M. Lee K. Kanemaru J. Ruiz-Orera V. Strohmenger D.M. DeLaughter G. Patone H. Zhang A. Woehler C. Lippert Y. Kim E. Adami J.M. Gorham S.N. Barnett K. Brown R.J. Buchan R.A. Chowdhury C. Constantinou J. Cranley L.E. Felkin H. Fox A. Ghauri J. Gummert M. Kanda R. Li L. Mach B. McDonough S. Samari F. Shahriaran C. Yapp C. Stanasiuk P.I. Theotokis F.J. Theis A. van den Bogaerdt H. Wakimoto J.S. Ware C.L. Worth P.J.R. Barton Y.A. Lee S.A. Teichmann H. Milting M. Noseda G.Y. Oudit M. Heinig J.G. Seidman N. Hubner C.E. Seidman August 12, 2022 / Front Mol Biosci Investigating the role of GLUL as a survival factor in cellular adaptation to glutamine depletion via targeted stable isotope resolved metabolomics S. Bayram Y.S. Razzaque S. Geisberger M. Pietzke S. Fürst C. Vechiatto M. Forbes G. Mastrobuoni S. Kempa November, 2022 / Andrology Analysis of copy number variation in men with non-obstructive azoospermia M.J. Wyrwoll R. Wabschke A. Röpke M. Wöste C. Ruckert S. Perrey N. Rotte J. Hardy L. Astica D.G. Lupianez J. Wistuba B. Westernströer S. Schlatt A.J. Berman A.M. Müller S. Kliesch A.N. Yatsenko F. Tüttelmann C. Friedrich September, 2022 / Sci Immunol C/EBPβ regulates lipid metabolism and Pparg isoform 2 expression in alveolar macrophages D. Dörr B. Obermayer J.M. Weiner K. Zimmermann C. Anania L.K. Wagner E.M. Lyras V. Sapozhnikova D. Lara-Astiaso F. Prósper R. Lang D.G. Lupiáñez D. Beule U.E. Höpken A. Leutz A. Mildner October 06, 2022 / Mol Cel SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA S. Maharana S. Kretschmer S. Hunger X. Yan D. Kuster S. Traikov T. Zillinger M. Gentzel S. Elangovan P. Dasgupta N. Chappidi N. Lucas K.I. Maser H. Maatz A. Rapp V. Marchand Y.T. Chang Y. Motorin N. Hubner G. Hartmann A.A. Hyman S. Alberti M.A. Lee-Kirsch December, 2022 / NAR Genom Bioinform AntiSplodge: a neural-network-based RNA-profile deconvolution pipeline designed for spatial transcriptomics J.B. Lund E.L. Lindberg H. Maatz F. Pottbaecker N. Hübner C. Lippert May 18, 2022 / Nat Commun HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins U. Zinnall M. Milek I. Minia C.H. Vieira-Vieira S. Müller G. Mastrobuoni O.G. Hazapis S. Del Giudice D. Schwefel N. Bley F. Voigt J.A. Chao S. Kempa S. Hüttelmaier M. Selbach M. Landthaler June 03, 2022 / Sci Adv Precise CRISPR/Cas-mediated gene repair with minimal off-target and unintended on-target mutations in human hematopoietic stem cells N.T. Tran E. Danner X. Li R. Graf M. Lebedin K. de la Rosa R. Kühn K. Rajewsky V.T. Chu Pagination Current page 1 Page 2 Next page Next › Last page Last »
February 09, 2022 / bioRxiv Spatio-temporal, optogenetic control of gene expression in organoids I. Legnini L. Emmenegger A. Zappulo R. Wurmus A. Oliveras Martinez C. Cerda Jara A. Boltengagen T. Hessler G. Mastrobuoni A. Rybak-Wolf S. Kempa R.P. Zinzen A. Woehler N. Rajewsky
March 22, 2022 / bioRxiv The little skate genome and the evolutionary emergence of wing-like fin appendages F. Marletaz E. de la Calle-Mustienes R.D. Acemel T. Nakamura C. Paliou S. Naranjo P.M. Martinez-Garcia I. Cases V.A. Sleight C. Hirschberger M. Marcet-Houben D. Navon A. Andrescavage K. Skvortsova P.E. Duckett A. Gonzalez-Rajal O. Bogdanovic J.H. Gibcus L. Yang L. Gallardo-Fuentes I. Sospedra J. Lopez-Rios F. Darbellay A. Visel J. Dekker N. Shubin T. Gabaldon J.J. Tena D.G. Lupianez D.S. Rokhsar J.L. Gomez-Skarmeta
August 05, 2022 / Science Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies D. Reichart E.L. Lindberg H. Maatz A.M.A. Miranda A. Viveiros N. Shvetsov A. Gärtner E.R. Nadelmann M. Lee K. Kanemaru J. Ruiz-Orera V. Strohmenger D.M. DeLaughter G. Patone H. Zhang A. Woehler C. Lippert Y. Kim E. Adami J.M. Gorham S.N. Barnett K. Brown R.J. Buchan R.A. Chowdhury C. Constantinou J. Cranley L.E. Felkin H. Fox A. Ghauri J. Gummert M. Kanda R. Li L. Mach B. McDonough S. Samari F. Shahriaran C. Yapp C. Stanasiuk P.I. Theotokis F.J. Theis A. van den Bogaerdt H. Wakimoto J.S. Ware C.L. Worth P.J.R. Barton Y.A. Lee S.A. Teichmann H. Milting M. Noseda G.Y. Oudit M. Heinig J.G. Seidman N. Hubner C.E. Seidman
August 12, 2022 / Front Mol Biosci Investigating the role of GLUL as a survival factor in cellular adaptation to glutamine depletion via targeted stable isotope resolved metabolomics S. Bayram Y.S. Razzaque S. Geisberger M. Pietzke S. Fürst C. Vechiatto M. Forbes G. Mastrobuoni S. Kempa
November, 2022 / Andrology Analysis of copy number variation in men with non-obstructive azoospermia M.J. Wyrwoll R. Wabschke A. Röpke M. Wöste C. Ruckert S. Perrey N. Rotte J. Hardy L. Astica D.G. Lupianez J. Wistuba B. Westernströer S. Schlatt A.J. Berman A.M. Müller S. Kliesch A.N. Yatsenko F. Tüttelmann C. Friedrich
September, 2022 / Sci Immunol C/EBPβ regulates lipid metabolism and Pparg isoform 2 expression in alveolar macrophages D. Dörr B. Obermayer J.M. Weiner K. Zimmermann C. Anania L.K. Wagner E.M. Lyras V. Sapozhnikova D. Lara-Astiaso F. Prósper R. Lang D.G. Lupiáñez D. Beule U.E. Höpken A. Leutz A. Mildner
October 06, 2022 / Mol Cel SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA S. Maharana S. Kretschmer S. Hunger X. Yan D. Kuster S. Traikov T. Zillinger M. Gentzel S. Elangovan P. Dasgupta N. Chappidi N. Lucas K.I. Maser H. Maatz A. Rapp V. Marchand Y.T. Chang Y. Motorin N. Hubner G. Hartmann A.A. Hyman S. Alberti M.A. Lee-Kirsch
December, 2022 / NAR Genom Bioinform AntiSplodge: a neural-network-based RNA-profile deconvolution pipeline designed for spatial transcriptomics J.B. Lund E.L. Lindberg H. Maatz F. Pottbaecker N. Hübner C. Lippert
May 18, 2022 / Nat Commun HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins U. Zinnall M. Milek I. Minia C.H. Vieira-Vieira S. Müller G. Mastrobuoni O.G. Hazapis S. Del Giudice D. Schwefel N. Bley F. Voigt J.A. Chao S. Kempa S. Hüttelmaier M. Selbach M. Landthaler
June 03, 2022 / Sci Adv Precise CRISPR/Cas-mediated gene repair with minimal off-target and unintended on-target mutations in human hematopoietic stem cells N.T. Tran E. Danner X. Li R. Graf M. Lebedin K. de la Rosa R. Kühn K. Rajewsky V.T. Chu