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Scientific Publications

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/ Cancer Discov

Passenger gene coamplifications create collateral therapeutic vulnerabilities in cancer

  • Y. Bei
  • Luca Brame
  • M. Kirchner
  • R. Fritsche-Guenther
  • S. Kunz
  • A. Bhattacharya
  • M.C. Rusu
  • D. Gürgen
  • F.P.B. Dubois
  • J.K.C. Köppke
  • J. Proba
  • N. Wittstruck
  • O.A. Sidorova
  • R. Chamorro González
  • H. Dorado Garcia
  • L. Brückner
  • R. Xu
  • M. Giurgiu
  • E. Rodriguez-Fos
  • Q. Yu
  • B. Spanjaard
  • R.P. Koche
  • C.A. Schmitt
  • J.H. Schulte
  • A. Eggert
  • K. Haase
  • J. Kirwan
  • A.I. Hagemann
  • P. Mertins
  • J.R. Dörr
  • A.G. Henssen
/ Genes Dev

Opposing roles of NF-κB in anti-cancer treatment outcome unveiled by cross-species investigations

  • H. Jing
  • J. Kase
  • J.R. Dörr
  • M. Milanovic
  • D. Lenze
  • M. Grau
  • G. Beuster
  • S. Ji
  • M. Reimann
  • P. Lenz
  • M. Hummel
  • B. Doerken
  • G. Lenz
  • C. Scheidereit
  • C.A. Schmitt
  • S. Lee
/ Virus Res

KSHV ORF67 encoded lytic protein localizes on the nuclear membrane and alters emerin distribution

  • A. Farina
  • R. Santarelli
  • R. Bloise
  • R. Gonnella
  • M. Granato
  • R. Bei
  • A. Modesti
  • M. Cirone
  • L. Bengtsson
  • A. Angeloni
  • A. Faggioni
/ Neuron

GlialCAM, a protein defective in a leukodystrophy, serves as a ClC-2 Cl(-) channel auxiliary subunit

  • E. Jeworutzki
  • T. Lopez-Hernandez
  • X. Capdevila-Nortes
  • S. Sirisi
  • L. Bengtsson
  • M. Montolio
  • G. Zifarelli
  • T. Arnedo
  • C.S. Mueller
  • U. Schulte
  • V. Nunes
  • A. Martinez
  • T.J. Jentsch
  • X. Gasull
  • M. Pusch
  • R. Estevez
/ Canc Cell

Tumor stroma-derived TGF-beta limits Myc-driven lymphomagenesis via Suv39h1-dependent senescence

  • M. Reimann
  • S. Lee
  • C. Loddenkemper
  • J.R. Dörr
  • V. Tabor
  • P. Aichele
  • H. Stein
  • B. Doerken
  • T. Jenuwein
  • C.A. Schmitt
/ Nature

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy

  • J.R. Dörr
  • Y. Yu
  • M. Milanovic
  • G. Beuster
  • C. Zasada
  • J.H.M. Däbritz
  • J. Lisec
  • D. Lenze
  • A. Gerhardt
  • K. Schleicher
  • S. Kratzat
  • B. Purfürst
  • S. Walenta
  • W. Mueller-Klieser
  • M. Gräler
  • M. Hummel
  • U. Keller
  • A.K. Buck
  • B. Dörken
  • L. Willmitzer
  • M. Reimann
  • S. Kempa
  • S. Lee
  • C.A. Schmitt
/ Mol Cancer Ther

CD20-targeting immunotherapy promotes cellular senescence in B-cell lymphoma

  • J.H.M. Däbritz
  • Y. Yu
  • M. Milanovic
  • M. Schönlein
  • M.T. Rosenfeldt
  • J.R. Dörr
  • A.M. Kaufmann
  • B. Dörken
  • C.A. Schmitt
/ Diabetes

Nrf2-mediated antioxidant defense and peroxiredoxin 6 are linked to biosynthesis of palmitic acid ester of 9-hydroxystearic acid

  • O. Kuda
  • M. Brezinova
  • J. Silhavy
  • V. Landa
  • V. Zidek
  • C. Dodia
  • F. Kreuchwig
  • M. Vrbacky
  • L. Balas
  • T. Durand
  • N. Hübner
  • A.B. Fisher
  • J. Kopecky
  • M. Pravenec
/ Nat Commun

Translational regulation shapes the molecular landscape of complex disease phenotypes

  • S. Schafer
  • E. Adami
  • M. Heinig
  • K.E. Costa Rodrigues
  • F. Kreuchwig
  • J. Silhavy
  • S. van Heesch
  • D. Simaite
  • N. Rajewsky
  • E. Cuppen
  • M. Pravenec
  • M. Vingron
  • S.A. Cook
  • N. Hubner
/ Genome Biol

A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion

  • F. Witte
  • J. Ruiz-Orera
  • C. Ciolli Mattioli
  • S. Blachut
  • E. Adami
  • J.F. Schulz
  • V. Schneider-Lunitz
  • O. Hummel
  • G. Patone
  • M.B. Mücke
  • Jan Šilhavý
  • M. Heinig
  • L. Bottolo
  • D. Sanchis
  • M. Vingron
  • M. Chekulaeva
  • M. Pravenec
  • N. Hubner
  • S. van Heesch