Scientific Publications

Piezo2 voltage-block regulates mechanical pain sensitivity

Novel tryptophan hydroxylase inhibitor TPT-001 reverses PAH, vascular remodeling, and proliferative-proinflammatory gene expression

Karyopherin α2 is a maternal effect gene required for early embryonic development and female fertility in mice

Discovery of tetrazolo-pyridazine-based small molecules as inhibitors of MACC1-driven cancer metastasis

Structure-based design of xanthine-imidazopyridines and -imidazothiazoles as highly potent and in vivo efficacious tryptophan hydroxylase inhibitors

CLK2 and CLK4 are regulators of DNA damage-induced NF-κB targeted by novel small molecule inhibitors

Transgenic angiotensin-converting enzyme 2 overexpression in the rat vasculature protects kidneys from ageing-induced injury

Small molecule specifically inhibiting microglial nitric oxide release could become a potential treatment for neuroinflammation

First in vivo fluorine-19 magnetic resonance imaging of the multiple sclerosis drug siponimod

January, 2023 / Nat Chem Biol

Development of selective inhibitors of phosphatidylinositol 3-kinase C2α