Scientific Publications

Immune response and metastasis-links between the metastasis driver MACC1 and cancer immune escape strategies

S. Torke
W. Walther
U. Stein

March 01, 2024 / Lancet Haematol

High-dose chemotherapy and autologous haematopoietic stem-cell transplantation in older, fit patients with primary diffuse large B-cell CNS lymphoma (MARTA): a single-arm, phase 2 trial

E. Schorb
L.K. Isbell
A. Kerkhoff
S. Mathas
F. Braulke
G. Egerer
A. Röth
S. Schliffke
P. Borchmann
U. Brunnberg
F. Kroschinsky
R. Möhle
A. Rank
D. Wellnitz
B. Kasenda
L. Pospiech
J. Wendler
F. Scherer
M. Deckert
E. Henkes
P. von Gottberg
D. Gmehlin
M. Backenstraß
A. Jensch
E. Burger-Martin
O. Grishina
H. Fricker
N. Malenica
A. Orbán
J. Duyster
G. Ihorst
J. Finke
G. Illerhaus

MACC1 regulates LGR5 to promote cancer stem cell properties in colorectal cancer

M. Erdem
K.H. Lee
M. Hardt
J.L. Regan
D. Kobelt
W. Walther
M. Mokrizkij
C. Regenbrecht
U. Stein

Structural analysis of PLD3 reveals insights into the mechanism of lysosomal 5' exonuclease-mediated nucleic acid degradation

Y. Roske
C. Cappel
N. Cremer
P. Hoffmann
T. Koudelka
A. Tholey
U. Heinemann
O. Daumke
M. Damme

Impact of the PI3Kalpha inhibitor alpelisib on everolimus resistance and somatostatin receptor expression in an orthotopic pancreatic NEC xenograft mouse model

A.M. Mohan
S. Prasad
F. Schmitz-Peiffer
C. Lange
M. Lukas
E.J. Koziolek
J. Albrecht
D. Messroghli
U. Stein
M. Ilmer
K. Wang
L. Schober
A. Reul
J. Maurer
J. Friemel
A. Weber
R.A. Zuellig
C. Hantel
R. Fritsch
M. Reincke
K. Pacak
A.B. Grossman
C.J. Auernhammer
F. Beuschlein
W. Brenner
N. Beindorff
S. Nölting

GIPC1 regulates MACC1-driven metastasis

F. Siegel
H. Schmidt
M. Juneja
J. Smith
P. Herrmann
D. Kobelt
K. Sharma
I. Fichtner
W. Walther
G. Dittmar
R. Volkmer
F.G. Rathjen
P.M. Schlag
U. Stein

Discovery of a non-canonical GRHL1 binding site using deep convolutional and recurrent neural networks

S. Proft
J. Leiz
U. Heinemann
D. Seelow
K.M. Schmidt-Ott
M. Rutkiewicz

H4K20me3 upregulated by reactive oxygen species is associated with tumor progression and poor prognosis in patients with hepatocellular carcinoma

S. Phoyen
A. Sanpavat
C. Ma-on
U. Stein
N. Hirankarn
P. Tangkijvanich
D. Jindatip
P. Whongsiri
C. Boonla

Discovery of tetrazolo-pyridazine-based small molecules as inhibitors of MACC1-driven cancer metastasis

S. Yan
P.C. Schöpe
J. Lewis
K. Putzker
U. Uhrig
E. Specker
J.P. von Kries
P. Lindemann
A. Omran
H.E. Sanchez-Ibarra
A. Unger
M.L. Zischinsky
B. Klebl
W. Walther
M. Nazaré
D. Kobelt
U. Stein

Structure-based design of xanthine-imidazopyridines and -imidazothiazoles as highly potent and in vivo efficacious tryptophan hydroxylase inhibitors

E. Specker
R. Wesolowski
A. Schütz
S. Matthes
K. Mallow
M. Wasinska-Kalwa
L. Winkler
A. Oder
N. Alenina
D. Pleimes
J.P. von Kries
U. Heinemann
M. Bader
M. Nazaré