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Scientific Publications

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/ Bio-protocol

Expansion and precise CRISPR-Cas9 gene repair of autologous T memory stem cells from patients with T cell immunodeficiencies

  • X. Li
  • V.T. Chu
  • C. Kocks
  • K. Rajewsky
/ Leukemia

In vivo CRISPR/Cas9-mediated screen reveals a critical function of TFDP1 and E2F4 transcription factors in hematopoiesis

  • N.T. Tran
  • R. Graf
  • E. Acevedo-Ochoa
  • J. Trombke
  • T. Weber
  • T. Sommermann
  • C. Salomon
  • R. Kühn
  • K. Rajewsky
  • V.T. Chu
/ Nat Cancer

The proteogenomic landscape of multiple myeloma reveals insights into disease biology and therapeutic opportunities

  • E. Ramberger
  • V. Sapozhnikova
  • Y.L.D. Ng
  • A. Dolnik
  • M. Ziehm
  • O. Popp
  • E. Sträng
  • M. Kull
  • F. Grünschläger
  • J. Krüger
  • M. Benary
  • S. Müller
  • X. Gao
  • A. Murgai
  • M. Haji
  • A. Schmidt
  • R. Lutz
  • A. Nogai
  • J. Braune
  • D. Laue
  • C. Langer
  • C. Khandanpour
  • F. Bassermann
  • H. Döhner
  • M. Engelhardt
  • C. Straka
  • M. Hundemer
  • D. Beule
  • S. Haas
  • U. Keller
  • H. Einsele
  • L. Bullinger
  • S. Knop
  • P. Mertins
  • J. Krönke
/ Sci Immunol

Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis

  • X. Li
  • T. Wirtz
  • T. Weber
  • M. Lebedin
  • E.D. Lowenstein
  • T. Sommermann
  • A. Zach
  • T. Yasuda
  • K. de la Rosa
  • V.T. Chu
  • J.H. Schulte
  • I. Müller
  • C. Kocks
  • K. Rajewsky
/ Cell Syst

Inference of differentiation trajectories by transfer learning across biological processes

  • G. Jumde
  • B. Spanjaard
  • J.P. Junker
/ Nat Commun

Direct-to-biology, automated, nano-scale synthesis, and phenotypic screening-enabled E3 ligase modulator discovery

  • Z. Wang
  • S. Shaabani
  • X. Gao
  • Y.L.D. Ng
  • V. Sapozhnikova
  • P. Mertins
  • J. Krönke
  • A. Dömling
/ J Med Chem

Leveraging ligand affinity and properties: discovery of novel benzamide-type cereblon binders for the design of PROTACs

  • C. Steinebach
  • A. Bricelj
  • A. Murgai
  • I. Sosič
  • L. Bischof
  • Y.L.D. Ng
  • C. Heim
  • S. Maiwald
  • M. Proj
  • R. Voget
  • F. Feller
  • J. Košmrlj
  • V. Sapozhnikova
  • A. Schmidt
  • M.R. Zuleeg
  • P. Lemnitzer
  • P. Mertins
  • F.K. Hansen
  • M. Gütschow
  • J. Krönke
  • M.D. Hartmann
/ Bio-protocol

Application of a spacer-nick gene-targeting approach to repair disease-causing mutations with increased safety

  • N.T. Tran
  • M. Lebedin
  • E. Danner
  • R. Kühn
  • K. Rajewsky
  • V.T. Chu
/ Mol Ther Nucleic Acids

Cas9-induced single cut enables highly efficient and template-free repair of a muscular dystrophy causing founder mutation

  • S. Müthel
  • A. Marg
  • B. Ignak
  • J. Kieshauer
  • H. Escobar
  • C. Stadelmann
  • S. Spuler
/ Int J Mol Sci

Disintegration of the NuRD complex in primary human muscle stem cells in critical illness myopathy

  • J. Schneider
  • D. Sundaravinayagam
  • A. Blume
  • A. Marg
  • S. Grunwald
  • E. Metzler
  • H. Escobar
  • S. Müthel
  • H. Wang
  • T. Wollersheim
  • S. Weber-Carstens
  • A. Akalin
  • M. Di Virgilio
  • B. Tursun
  • S. Spuler