Header BSM 2023

16th Berlin Summer Meeting: The MDC celebrates 15 years of BIMSB

2023 marks the 15-year anniversary of the Berlin Institute for Medical Systems Biology (BIMSB), founded in 2008 as part of the Max Delbrück Center. To honor this milestone, our annual Berlin Summer Meeting Meeting – which, along with the BIMSB, has also been established in 2008 – will be held under the motto “The MDC celebrates 15 years of BIMSB”. The meeting is jointly organized by the Topic 1 Faculty.

The Berlin Summer Meeting: Computational and Experimental Biology Meet brings together scientists at the interface of experimental molecular biology and computational biology and connects young researchers with top-level senior scientists. This year’s Berlin Summer Meeting will showcase exciting new developments in the field of systems biology, work by BIMSB alumni as well as science which has been highly impactful for us – and we are excited to be hosting a fantastic selection of international experts!

To reflect the founding and early years of the BIMSB on the Campus Buch and the subsequent move to a dedicated research building in the center of Berlin, the first day of the meeting will be held in the Max Delbrück Communications Center in Berlin-Buch, and the second day will take place in the centrally located Langenbeck-Virchow-Haus. The meeting will conclude with a retrospective 15 years MDC-BIMSB with evening reception at the MDC location in Berlin-Mitte (MDC-BIMSB research building).

If you require childcare, please let us know no later than Aug 28th via E-mail: BIMSB.Events@mdc-berlin.de



Early Bird End: August 15, 2023

Registration Fee Overview

Full registration fee (early) 350,00 €
Full registration fee (late) 450,00 €
External students 200,00 €
MDC employees 200,00 €
MDC Students 100,00 €



MDC (Buch) & Langenbeck-Virchow-Haus
Robert-Rössle-Straße 10 bzw. Luisenstraße 58/59
13125 Berlin


Campus Plan


Wednesday, September 6, 2023

MDC.C Max Delbrück Communications Center,

Campus Buch, Robert-Rössle-Str. 10, 13125 Berlin

9:00 am – 9:15 am Welcome address by Maike Sander and Nikolaus Rajewsky

Session 1 Host:
Nikolaus Rajewsky

9:15 am – 10:00 am           Bernd Bodenmiller (University of Zurich, ETH Zurich, Switzerland)

10:00 am – 10:15 am        Nora Fresmann (MDC-BIMSB, Berlin, Germany)
Cause and consequence of intra- and inter-tumor heterogeneity in zebrafish models of neuroblastoma

10:15 am – 11:00 am        Hans Clevers (Roche Pharma Research and Early Development Roche Innovation Center Basel, Switzerland)
Organoids to model human disease

11:00 am – 11:30 am        Coffee break

Session 2 Host: Nikolaus Rajewsky: ((MDC-BIMSB Alumni Session)

11:30 am – 11:50 pm        Pinar Önal (Bilkent University, Ankara, Turkey)
Evolutionary dynamics of a robust transcriptional network

11:50 am – 12:10 pm        Baris Tursun (Universität Hamburg, Germany)
A reprogrammed worms perspective on BIMSB

12:10 pm – 12:30 pm        Elena Torlai Triglia (Broad Institute, Cambridge, MA, USA)
Identifying molecular determinants of cancer phenotypes with edited human cell models

12:30 pm – 12:50 pm        Lea Gregersen (University of Copenhagen, Denmark)
Oxidative stress triggers a unique and transient dynamic transcriptional response

12:50 pm – 1:10 pm           Mathias Munschauer (Helmholtz Institute for RNA-based Infection Research, Würzburg, Germany)
The host protein SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis

1:10 pm – 3:00 pm Lunch & Poster session

Session 3 Host: Markus Landthaler

3:00 pm – 3:45 pm             Dominic Grün (University of Würzburg, Germany)
Reconstructing cell fate decision in time and space

3:45 pm – 4:00 pm             Till Schwämmle (Max Planck Institute for Molecular Genetics, Berlin, Germany)
Zic3 and Otx2 link Xist activation to the formative pluripotency network

4:00 pm – 4:15 pm             Lisa Buchauer (Charité - Universitätsmedizin Berlin, Germany / Weizmann Institute of Science, Rehovot, Israel)
Spatial discordances between mRNAs and proteins in the intestinal epithelium

4:15 pm – 5:00 pm             Gene Yeo (University of California, San Diego, CA, USA)
RNA binding protein networks in health and disease

Thursday, September 7, 2023

Langenbeck-Virchow-Haus, Luisenstr. 58/59, 10117 Berlin

Session 4 Host: Ana Pombo

9:00 am – 9:45 am             Patrick Cramer (MPI for Multidisciplinary Sciences, Göttingen, Germany)
New insights into transcription regulation

9:45 am – 10:00 am           Tancredi Pentimalli (MDC-BIMSB, Berlin, Germany)
3D molecular reconstruction of a human tumor at single-cell resolution reveals invasion dynamics and predicts mechanism-based, personalized therapeutic targets

10:00 am – 10:15 am        Mikaela Behm (DKFZ, Heidelberg, Germany)
An interactive cellular ecosystem blocks epithelial transformation in naked mole-rat

10:15 am – 11:00 am        Stephan Preibisch (Janelia Research Campus, Ashburn, VA, USA)
Peta-scale microscopy – challenges, solutions and possibilities

11:00 – 11:30 Coffee break

Session 5 Host: Ashley Sanders

11:30 am – 12:15 am        Nada Jabado (McGill University Health Centre, Montreal, Canada)
Oncohistone in disease: from cancer to neurodegeneration and beyond

12:15 pm – 12:30 pm        Max Trauernicht (Netherlands Cancer Institute, Amsterdam / Oncode Institute, Utrecht, the Netherlands)
Multiplexed detection of transcription factor activity

12:30 pm – 12:45 pm        Andréa Willemin (MDC-BIMSB, Berlin, Germany)
A GAM-based approach to explore the contribution of proteins or PTMs to 3D genome folding and cellular state transitions

12:45 am – 1:30 pm           Stein Aerts (KU Leuven Center for Human Genetics and the VIB Center Disease Research, Belgium)
Single-cell driven enhancer modelling and design

1:30 pm                      Group photo

1:30 pm – 3:00 pm     Lunch break

Session 6 Host: Stefanie Grosswendt

3:00 pm – 3:45 pm             Amos Tanay (Weizmann Institute of Science, Rehovot, Israel)
Profiling and modelling the blood to understand disease progression

3:45 pm – 4:30 pm             Tuuli Lappalainen (New York Genome Center, New York City, NY, USA, and KTH Royal Institute of Technology and SciLifeLab, Stockholm, Sweden)
Genetic effects on gene expression dosage underlying cellular and physiological phenotypes

4:30 pm – 5:15 pm             Sara Wickström (MPI for Molecular Biomedicine, Münster, Germany)
Coordination of cell states and tissue architecture by mechanical forces

5:15 pm                     Closing remarks

5:30 pm                     Reception, MDC-BIMSB, Hannoversche Str. 28, 10115 Berlin (5 min walking distance from the meeting venue)

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