Science May 11, 2006 The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment A specialized quality control system samples the endoplasmic reticulum (ER) for proteins that...
Science April 21, 2006 A structural role for ATP in the formation and stability of the human origin recognition complex In the yeast S. cerevisiae, origins of DNA replication are defined by the recruitment of the...
Science April 18, 2006 Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biochemical and ischemic stress The apoptosis-repressor-with-CARD (ARC) is a recently discovered anti-apoptotic factor with a highly...
Science April 10, 2006 Sleeping Beauty transposase modulates cell-cycle progression through interaction with Miz-1 Transposable elements (transposons) are segments of DNA with the ability to move from one location...
Science March 23, 2006 Cardiac hypertrophy in transgenic rats expressing a dominant negative mutant of the natriuretic peptide receptor B The family of natriuretic peptides (NP) consists of the structurally homologous but genetically...
Science March 17, 2006 Running in pregnancy transiently increases postnatal hippocampal neurogenesis in the offspring Activity influences brain anatomy and function across the lifespan of the individual. While it is...
Science March 08, 2006 NF- κB transmits Eda A1/EdaR signalling to activate Shh and cyclin D1 expression, and controls post-initiaion hair placode down growth The transcription factor, NF- κB, is required for normal development of epidermal appendages...
Science March 02, 2006 Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma Hodgkin lymphoma (HL) is characterized by the malignant growth of the so-called Hodgkin/Reed...
Science January 25, 2006 Natural variation and genetic covariance in adult hippocampal neurogenesis Adult neurogenesis refers to the neuronal development within the adult brain- a process which is...
Science December 06, 2005 Heart and soul/PRKCi and nagie oko/Mpp5 regulate myocardial coherence and remodeling during cardiac morphogenesis. Organ morphogenesis requires cellular shape changes and tissue rearrangements that occur in a...