BLN protein induces cardiac hypertrophy and failure
Autor/innen
- S.R. Sperling
Journal
- Nature Cardiovascular Research
Quellenangabe
- Nat Cardiovasc Res 2 (11): 964-965
Zusammenfassung
BBLN, a protein with predominantly uncharted functions, serves as an instigator of CAMK2D autophosphorylation, leading to subsequent cardiac remodeling and failure in both humans and mice. The induction of BBLN is driven by hypoxia in TOF and/or pressure overload, as evidenced in mouse models.