Regulation of the germinal center response by microRNA-155
Autor/innen
- T.H. Thai
- D.P. Calado
- S. Casola
- K.M. Ansel
- C. Xiao
- Y. Xue
- A. Murphy
- D. Frendewey
- D. Valenzuela
- J.L. Kutok
- M. Schmidt-Supprian
- N. Rajewsky
- G. Yancopoulos
- A. Rao
- K. Rajewsky
Journal
- Science
Quellenangabe
- Science 316 (5824): 604-608
Zusammenfassung
MicroRNAs are small RNA species involved in biological control at multiple levels. Using genetic deletion and transgenic approaches, we show that the evolutionarily conserved microRNA-155 (miR-155) has an important role in the mammalian immune system, specifically in regulating T helper cell differentiation and the germinal center reaction to produce an optimal T cell-dependent antibody response. miR-155 exerts this control, at least in part, by regulating cytokine production. These results also suggest that individual microRNAs can exert critical control over mammalian differentiation processes in vivo.