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Studies in zebrafish and rat models support dual blockade of EP2 and EP4 (prostaglandin E(2) receptors type 2 and 4) for renoprotection in glomerular hyperfiltration and albuminuria

A. Kourpa
A. Schulz
E. Mangelsen
D. Kaiser-Graf
N. Koppers
M. Stoll
M. Rothe
M. Bader
B. Purfürst
S. Kunz
T. Gladytz
T. Niendorf
S. Bachmann
K. Mutig
J. Bolbrinker
D. Panakova
R. Kreutz

Lack of evidence for participation of TMEM150C in sensory mechanotransduction

J. Ojeda-Alonso
V. Bégay
J.A. Garcia-Contreras
A.F. Campos-Pérez
B. Purfürst
G.R. Lewin

Investigating the role of GLUL as a survival factor in cellular adaptation to glutamine depletion via targeted stable isotope resolved metabolomics

S. Bayram
Y.S. Razzaque
S. Geisberger
M. Pietzke
S. Fürst
C. Vechiatto
M. Forbes
G. Mastrobuoni
S. Kempa

HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins

U. Zinnall
M. Milek
I. Minia
C.H. Vieira-Vieira
S. Müller
G. Mastrobuoni
O.G. Hazapis
S. Del Giudice
D. Schwefel
N. Bley
F. Voigt
J.A. Chao
S. Kempa
S. Hüttelmaier
M. Selbach
M. Landthaler

11. November 2021 / Nature

Virus-induced senescence is driver and therapeutic target in COVID-19

S. Lee
Y. Yu
J. Trimpert
F. Benthani
M. Mairhofer
P. Richter-Pechanska
E. Wyler
D. Belenki
S. Kaltenbrunner
M. Pammer
L. Kausche
T.C. Firsching
K. Dietert
M. Schotsaert
C. Martínez-Romero
G. Singh
S. Kunz
D. Niemeyer
R. Ghanem
H.J.F. Salzer
C. Paar
M. Mülleder
M. Uccellini
E.G. Michaelis
A. Khan
A. Lau
M. Schönlein
A. Habringer
J. Tomasits
J.M. Adler
S. Kimeswenger
A.D. Gruber
W. Hoetzenecker
H. Steinkellner
B. Purfuerst
R. Motz
F. Di Pierro
B. Lamprecht
N. Osterrieder
M. Landthaler
C. Drosten
A. García-Sastre
R. Langer
M. Ralser
R. Eils
M. Reimann
D.N.Y. Fan
C.A. Schmitt

Age-related decline in murine heart and skeletal muscle performance is attenuated by reduced Ahnak1 expression

S. Mahmoodzadeh
K. Koch
C. Schriever
J. Xu
M. Steinecker
J. Leber
E. Dworatzek
B. Purfürst
S. Kunz
D. Recchia
M. Canepari
A. Heuser
S. Di Francescantonio
I. Morano

Identification of disease-relevant modulators of the SHH pathway in the developing brain

N. Mecklenburg
I. Kowalczyk
F. Witte
J. Görne
A. Laier
T.M. Mamo
H. Gonschior
M. Lehmann
M. Richter
A. Sporbert
B. Purfürst
N. Hübner
A. Hammes

Inhibiting PHGDH with NCT-503 reroutes glucose-derived carbons into the TCA cycle, independently of its on-target effect

B. Arlt
G. Mastrobuoni
J. Wuenschel
K. Astrahantseff
A. Eggert
S. Kempa
H.E. Deubzer

Inhibiting phosphoglycerate dehydrogenase counteracts chemotherapeutic efficacy against MYCN-amplified neuroblastoma

B. Arlt
C. Zasada
K. Baum
J. Wuenschel
G. Mastrobuoni
M. Lodrini
K. Astrahantseff
A. Winkler
J.H. Schulte
S. Finkler
M. Forbes
P. Hundsdoerfer
D. Guergen
J. Hoffmann
J. Wolf
A. Eggert
S. Kempa
H.E. Deubzer