Keller Lab
Mechanism-based Cancer Therapies
Profile
Cancer originates from normal cells through genetic and epigenetic alterations. By employing forward genomic screening we start from a known gene mutation or cancer-associated condition and investigate the path that results in a manifest malignancy. Major further focus areas of the lab include: oncoprotein-induced disturbance of post-translational protein modifications, in particular SUMOylation, and sensing of DNA damage; constitutively activated B-cell receptor and chemokine receptor signaling; and molecular cancer imaging and theranostics.
Team
Group Leader
Prof. Dr. med. Ulrich Keller
Team
Sarah Al-Tabatabaee, MD Student (Busse group)
Stefanos Bamopoulos, Dr. med., Clinician Scientist
Francis Baumgartner, Dr. med., Clinician Scientist
Marlitt Böger, PhD Student
Antonia Busse, PD Dr. med., Clinician Scientist, Team Leader, Sub-PI
Nese Cakmak, Dr. rer. nat., Scientist (Busse group)
Uta Demel, Dr. med., Clinician Scientist
Falk Fabian, MD Student (Busse group)
Cäcilia Freund, Technical Assistant (Busse group)
Sanket Gosavi, Student
Corinna Grunert, PhD Student (Busse group)
Stefan Habringer, Dr. med. Dr. univ., Clinician Scientist, Team Leader
Gustaaf Heynen, Dr. rer. nat., Scientist
Maximilian Holz, MD Student
Konstandina Isaakidis, M.Sc., Lab Manager
Kaiting Jiang, MD Student
Hazal Köse, PhD Student
Ran Li, MD Student (Busse group)
Hongyu Liu, Dr. rer. medic., Staff Scientist
Anna Meurer, Clinician Scientist
Maja Milanovic, Dr. rer. nat., Scientist
Caroline Anna Peuker, Dr. med., Clinician Scientist (Busse group)
Simone Rhein, Dr. rer. nat., Scientist (Busse group; affiliation EPO GmbH)
Markus Schick, Dr. rer. nat., Associated Scientist
Laura Schmalbrock, Dr. med., Clinician Scientist
Paula Schmidt, MD Student (Busse group)
Veronika Schulze, M.Sc., Technical Assistant
Emina Sivro, PhD Student (Busse group)
Daniel Steiert, PhD Student
Isabelle Träger, MD Student
Sara Uhan, PhD Student
Philine Wegner, PhD Student
Matthias Wirth, PD Dr. rer. nat., Scientist, Team Leader
Sarvenaz Yaghobramzi, MD Student (Busse group)
Chuanbing Zang, Dr. rer. medic., Staff Scientist
Le Zhang, MD Student
Research
- Myc-associated cancer biology
-
- Functional genomic screening
-
- Aberrant Ub/SUMO activity in cancer
-
- Chemokine receptor signaling
-
- Functional imaging and theranostics
-
Publications
News
Funding
-
Berlin Institute of Health (BIH)
-
Berliner Krebsgesellschaft
-
Bundesamt für Risikobewertung (BfR)
-
Bundesministerium für Bildung und Forschung (BMBF)
-
Deutsche Forschungsgemeinschaft (DFG)
-
Deutsche Krebshilfe
-
Else Kröner Fresenius Stiftung (EKFS)
-
German Cancer Consortium (DKTK)
-
Sonnenfeld-Stiftung
-
Stiftung Charité
-
Wilhelm-Sander-Stiftung