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Press Release No. 3 Berlin

How a protein fights off bacteria

The details of many immune defense mechanisms are still unknown, but a new study sheds light on one such mechanism. Writing in “The EMBO Journal”, researchers led by Oliver Daumke and Misha Kudryashev of the Max Delbrück Center describe exactly how GBP1 proteins render bacteria harmless by encapsulating them.
Press Release No. 6 Berlin

Ischemic renal failure and organ damage: a new mouse model holds the key

Every year acute renal failure affects over 13 million people and leads to 1.7 million deaths across the globe.It often develops when an insufficient supply of oxygen reaches the kidneys, a condition called ischemia. Working with their colleagues from the MDC, the Charité and FMP in Berlin and Hannover Medical School, Dr Lajos Markó and Emilia Vigolo have traced one of the causes of ischemia-related renal failure to a signaling molecule called NF-κB and a specific type of tissue: tubular epithelial cells. Suppressing NF-κB signaling in these renal cells almost entirely eliminates the fatal tissue damage and inflammatory responses that accompany the disease.
Press Release No. 27 Berlin

Insulin-sensitive fat leads to obesity

SORLA is part of a machinery within cells that sorts proteins to processing where they are either...
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Press Release No. 12 Berlin

DASH - A diet to reduce high blood pressure

Overweight and obesity are a major risk factor for ill health, especially high blood pressure (hypertension) and diabetes.
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Press Release No. 28 Berlin

First International Graduate School for Skeletal Muscle Diseases Partners: MDC, Charité Berlin and Université Pierre et Marie Curie Paris VI

There are approximately 400 different skeletal muscle diseases, each of which is rare and incurable. Furthermore, there is no structured platform for PhD training in this field. This shall soon change.
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Press Release No. 20 Berlin

Professor Thomas Willnow: Clearer Insights into the Development of Alzheimer’s Disease

Multiple Research Approaches at the MDC - Alzheimer’s disease affects approximately 35 million people worldwide, and currently one million people are estimated to be affected in Germany.
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Press Release No. 1 Berlin

MDC Researchers and Clinical Partners Identify Mediator of Blood Pressure Regulation in the Liver - Pressor Reflex Triggered Simply by Drinking Water

For 60 years, scientists have puzzled over the possibility of a hepatic osmoreceptor that influences blood pressure regulation. Now, researchers of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch, the Experimental and Clinical Research Center (ECRC) of the MDC and Charité and the Hannover Medical School (MHH) appear to have made a breakthrough discovery.
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Press Release No. 24 Berlin

From Vancouver to Berlin: W3 Professorship for Bioinformatician Irmtraud Meyer at the FU Berlin and the Max Delbrück Center

The bioinformatician Irmtraud Meyer of the University of British Columbia in Vancouver, Canada, has accepted the appointment to a W3 professorship for “Bioinformatics of the RNA Structure and Transcriptome Regulation” at the Freie Universität Berlin (FU) in cooperation with the Berlin Institute for Medical Systems Biology (BIMSB) of the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC). The two institutions have thus succeeded in recruiting an internationally recognized scientist to Berlin and to strengthen the field of systems biology and systems medicine. Professor Meyer will begin her work in Berlin during this winter term and thus return to Germany after 16 years of research abroad.
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Press Release No. 9 Berlin

Hypertension Specialist and Nephrologist, Friedrich C. Luft, Turns 70 years

Friedrich C. Luft MD, Director of the Experimental and Clinical Research Center (ECRC) of the Charité Medical Faculty, Berlin, and the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch, celebrated his 70th birthday on March 4th, 2012. The nephrologist and hypertension specialist also heads his own research group at the MDC. The research activities of the clinician-researcher focus on the genetics of hypertension and hypertension-related target-organ damage.
Structure model of the new protein complex
Press Release No. 45 Berlin

Disturbance wanted – Newly characterized protein interaction may help in search for new cancer-fighting drugs

Some anticancer agents intend to disturb the function of the p97 protein complex, which is essential for survival of cancer cells. A team of researchers of the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) has now found a way to break up the p97 complex into its subunits and published their results in Nature Communications.