An intrinsic interferon program protects stem cells from viral infection
Authors
- S. Haas
- A. Trumpp
Journal
- Developmental Cell
Citation
- Dev Cell 44 (3): 279-280
Abstract
Specific protection mechanisms are required to safeguard stem cell integrity. In a recent issue of Cell, Wu et al. (2018) show that stem cells are equipped with high intrinsic expression of interferon-stimulated genes (ISGs) but remain refractory to acute interferon signaling. This protects stem cells from viral infection.