Mortality of neuromyelitis optica spectrum disorder patients in an Argentinean population: a study from the RelevarEM registry
Authors
- E. Carnero Contentti
- P.A. Lopez
- J.P. Pettinicchi
- J. Criniti
- A. Pappolla
- J. Miguez
- E. Cristiano
- L. Patrucco
- S. Liwacki
- V. Tkachuk
- M.E. Balbuena
- C. Vrech
- N. Deri
- J. Correale
- M. Marrodan
- M.C. Ysrraelit
- F. Leguizamon
- G. Luetic
- M.L. Menichini
- D. Tavolini
- C. Mainella
- G. Zanga
- M. Burgos
- J. Hryb
- A. Barboza
- L. Lazaro
- R. Alonso
- N. Fernández Liguori
- D. Nadur
- M. Alonso Serena
- A. Caride
- F. Paul
- J.I. Rojas
Journal
- Multiple Sclerosis Journal Experimental Translational and Clinical
Citation
- Mult Scler J Exp Transl Clin 9 (4): 20552173231205444
Abstract
We aimed to evaluate mortality and causes of death among Argentinean neuromyelitis optica spectrum disorder (NMOSD) patients and identify predictors of death. Retrospective study included 158 NMOSD patients and 11 (7%) patients died after 11 years of follow-up for a total exposure time of 53,345 days with an overall incidence density of 2.06 × 10.000 patients/day (95% CI 1.75-2.68). Extensive cervical myelitis with respiratory failure (45%) was the most frequent cause of death. Older age (HR = 2.05, p = 0.002) and higher disability score (HR = 2.30, p < 0.001) at disease onset were independent predictors of death. We found an 11-year mortality rate of 7% in Argentinean NMOSD patients.