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A novel allele for inducible Cre expression in germinal center B cells

Authors

  • T. Weber
  • J. Seagal
  • W. Winkler
  • T. Wirtz
  • V.T. Chu
  • K. Rajewsky

Journal

  • European Journal of Immunology

Citation

  • Eur J Immunol 49 (1): 192-194

Abstract

  • The germinal center reaction is essential for efficient humoral immunity, but it can also give rise to B cell lymphomas. Cre/loxP-mediated conditional gene knock-out or knock-in can be used for the genetic manipulation of germinal center B cells in vivo. Here we present a novel allele, Cγ1-CreERT2, that allows for timed activation of Cre recombinase in a small fraction of germinal center B cells. This allele will be useful to study normal and malignant germinal center B cell development in vivo.


DOI

doi:10.1002/eji.201847863