Rats, salt, and history
Authors
- F.C. Luft
Journal
- Cell Metabolism
Citation
- Cell Metab 15 (2): 129-130
Abstract
The Dahl salt-sensitive rat is a 50-year-old enigma in hypertension research. How does salt increase blood pressure? One hypothesis put forward is the involvement of reactive oxygen species produced in the renal outer medulla. A novel rat gene-deletion model in this issue of Cell Metabolism supports this argument.