Solute excretion, metabolism, and cardio-renoprotection via two distinct mechanisms revolutionize clinical outcomes

Two pharmacological principles, one at least 80 years old and another over 60 years old have recently come to fruition. The first, phlorizin, was thought to cause diabetes, but then a closer look revealed a renal mechanism that was independent of insulin or insulin deficiency. Research into its action facilitated the discovery of sodium-dependent glucose transporters. The second compound came close on the heels of the discovery that the mineralocorticoid, aldosterone, can be released through the action of angiotensin II.