Research and Technologies

Research and Technologies

Research at MDC-BIMSB is focused on understanding all levels of gene regulatory networks in both health and disease states - epigenetic, transcriptional and post-transcriptional processes as well as major cellular regulatory mechanisms, such as protein-protein and protein-nucleic acid interaction networks, signal transduction pathways, post-translational modifications and metabolic feedback. The aim is to generate quantitative models that predict how genes and their products act in concert to give rise to specific phenotypes.

MDC-BIMSB researchers develop and apply high-throughput technologies and computational modeling to in vitro disease models, model organisms, and clinical and epidemiological data sets. Leveraging single-cell technologies, spatial multi-omics and machine learning approaches, they establish workflows to analyze spatially and temporally resolved gene expression patterns in individual cells and across tissues. Major research projects address basic cell biology, developmental biology, regeneration, stem cell biology, immunology, genetic variability as well as health questions including cancer, obesity, metabolism, cardiovascular, gastrointestinal, renal and neurodegenerative diseases. Our long-term goal is the improvement of both diagnosis and therapy through personalized medicine by facilitating specific targeting of treatment regimens to subsets of responding patients.