Topic 3 of our research program "Systems Medicine and Cardiovascular Diseases"
Integrative Biomedicine investigates how different organs and systems communicate with each other to maintain a healthy balance in our body (homeostasis). When these cross-talks are perturbed, multi-organ pathological conditions arise.
Today, the greatest challenges to our health, life expectancy and quality of life are associated with the progressive or acute failure of cardiovascular, neuronal and immune functions, and the emergence of cancers. All of these pathological conditions involve multiple organs. To understand their origin, progression and protective factors, we need to develop a systems-wide, transdisciplinary approach.
To uncover and modulate systems-wide principles of homeostasis, we combine genetic engineering, advanced imaging, in-bulk and single-cell multi-omics, multi-parameter phenotypical and behavioural characterization in model systems of varying complexity. These include humanized disease models ranging from engineered cells and tissues to preclinical animal models, patient-derived cells and cohorts.